Comparison of energy balance in two inbred strains of rats: Fischer F344 prone to obesity and Lou rats resistant to obesity

Abdoulaye Diane, Sandrine Wetzler, Marc Goubern, Jean Marie Helies, Gilles Fromentin, Daniel Tomé, Christiane Larue-Achagiotis

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This study aimed to compare energy balance, metabolic profiles and body composition between two inbred strains of rats (F344 and Lou) submitted to a self-selecting macronutrient. During the 3 weeks of experiment, the two strains did not differ significantly for their total energy intake; males: F344 = 5875.4 ± 171.4 kJ, Lou = 5619.2 ± 349.4 kJ; and females: F344 = 4058.8 ± 118.7 kJ, Lou = 3864.4 ± 166.4 kJ. However, F344 rats showed a higher weight gain, and percentage of total fat tissue, together with a lower percentage of carcass weight than Lou rats regardless of sex. The percentages of each macronutrient revealed a lower preference of protein for F344 males and the opposite in females for CHO. The thermogenic activity measured in interscapular brown adipose tissue was lower in Fischer than in Lou while the reverse was observed for leptinemia and insulinemia. These results indicate that the mechanism responsible for the regulation of body composition observed in Lou rats takes place very early in life and attest the interest in this strain for studying the features of resistance to obesity.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalPhysiology and Behavior
Volume87
Issue number2
DOIs
Publication statusPublished - 28 Feb 2006
Externally publishedYes

Fingerprint

Inbred Strains Rats
Body Composition
Obesity
Brown Adipose Tissue
Metabolome
Inbred F344 Rats
Energy Intake
Weight Gain
Fats
Weights and Measures
Proteins

Keywords

  • BAT
  • Body composition
  • Food choice
  • Thermogenesis
  • WAT

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Diane, A., Wetzler, S., Goubern, M., Helies, J. M., Fromentin, G., Tomé, D., & Larue-Achagiotis, C. (2006). Comparison of energy balance in two inbred strains of rats: Fischer F344 prone to obesity and Lou rats resistant to obesity. Physiology and Behavior, 87(2), 245-250. https://doi.org/10.1016/j.physbeh.2005.09.014

Comparison of energy balance in two inbred strains of rats : Fischer F344 prone to obesity and Lou rats resistant to obesity. / Diane, Abdoulaye; Wetzler, Sandrine; Goubern, Marc; Helies, Jean Marie; Fromentin, Gilles; Tomé, Daniel; Larue-Achagiotis, Christiane.

In: Physiology and Behavior, Vol. 87, No. 2, 28.02.2006, p. 245-250.

Research output: Contribution to journalArticle

Diane, A, Wetzler, S, Goubern, M, Helies, JM, Fromentin, G, Tomé, D & Larue-Achagiotis, C 2006, 'Comparison of energy balance in two inbred strains of rats: Fischer F344 prone to obesity and Lou rats resistant to obesity', Physiology and Behavior, vol. 87, no. 2, pp. 245-250. https://doi.org/10.1016/j.physbeh.2005.09.014
Diane, Abdoulaye ; Wetzler, Sandrine ; Goubern, Marc ; Helies, Jean Marie ; Fromentin, Gilles ; Tomé, Daniel ; Larue-Achagiotis, Christiane. / Comparison of energy balance in two inbred strains of rats : Fischer F344 prone to obesity and Lou rats resistant to obesity. In: Physiology and Behavior. 2006 ; Vol. 87, No. 2. pp. 245-250.
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