Abstract
Objectives: Extensive peritumoral neoplastic lymphovascular invasion (ePVI) is a marker of aggressiveness in invasive breast carcinoma (BC).
Methods: We explored the impact of ePVI on different BC subtypes. In a total of 2,116 BCs, 91 ePVI-BCs, 70 inflammatory breast carcinomas (IBCs), and 114 casual BCs as a control group (CG-BC) were recruited.
Results: Patients affected by ePVI-BC were younger, had larger tumors, higher histologic grade, elevated Ki-67 score, Her2/neu overexpressed, and more lymph node metastases compared with CG-BC (P <.001). Interestingly, only younger mean age at diagnosis differentiated patients with ePVI-BC from patients affected by IBC. ePVI-BC showed a clinical outcome intermediate between the prognoses of IBC and CG-BC.
Conclusions: Results suggest that ePVI-BC and IBC may share some pathologic processes, providing a novel perspective on the heterogeneity of BC. Epidemiologic data and molecular studies on gene expression features are needed to rationally classify these tumors into their identified subtypes.
| Original language | English |
|---|---|
| Pages (from-to) | 299-306 |
| Number of pages | 8 |
| Journal | American Journal of Clinical Pathology |
| Volume | 142 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Jan 2014 |
| Externally published | Yes |
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Keywords
- Inflammatory breast carcinoma
- Invasive breast cancer
ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
Comparison between Invasive Breast Cancer with Extensive Peritumoral Vascular Invasion and Inflammatory Breast Carcinoma : A Clinicopathologic Study of 161 Cases. / Manfrin, Erminia; Remo, Andrea; Pancione, Massimo; Cannizzaro, Claudia; Falsirollo, Francesca; Pollini, Giovanni Paolo; Pellini, Francesca; Molino, Annamaria; Brunelli, Matteo; Vendraminelli, Roberto; Ceccarelli, Michele; Pagnotta, Stefano Maria; Simeone, Ines; Bonetti, Franco.
In: American Journal of Clinical Pathology, Vol. 142, No. 3, 01.01.2014, p. 299-306.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison between Invasive Breast Cancer with Extensive Peritumoral Vascular Invasion and Inflammatory Breast Carcinoma
T2 - A Clinicopathologic Study of 161 Cases
AU - Manfrin, Erminia
AU - Remo, Andrea
AU - Pancione, Massimo
AU - Cannizzaro, Claudia
AU - Falsirollo, Francesca
AU - Pollini, Giovanni Paolo
AU - Pellini, Francesca
AU - Molino, Annamaria
AU - Brunelli, Matteo
AU - Vendraminelli, Roberto
AU - Ceccarelli, Michele
AU - Pagnotta, Stefano Maria
AU - Simeone, Ines
AU - Bonetti, Franco
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Objectives: Extensive peritumoral neoplastic lymphovascular invasion (ePVI) is a marker of aggressiveness in invasive breast carcinoma (BC).Methods: We explored the impact of ePVI on different BC subtypes. In a total of 2,116 BCs, 91 ePVI-BCs, 70 inflammatory breast carcinomas (IBCs), and 114 casual BCs as a control group (CG-BC) were recruited.Results: Patients affected by ePVI-BC were younger, had larger tumors, higher histologic grade, elevated Ki-67 score, Her2/neu overexpressed, and more lymph node metastases compared with CG-BC (P <.001). Interestingly, only younger mean age at diagnosis differentiated patients with ePVI-BC from patients affected by IBC. ePVI-BC showed a clinical outcome intermediate between the prognoses of IBC and CG-BC.Conclusions: Results suggest that ePVI-BC and IBC may share some pathologic processes, providing a novel perspective on the heterogeneity of BC. Epidemiologic data and molecular studies on gene expression features are needed to rationally classify these tumors into their identified subtypes.
AB - Objectives: Extensive peritumoral neoplastic lymphovascular invasion (ePVI) is a marker of aggressiveness in invasive breast carcinoma (BC).Methods: We explored the impact of ePVI on different BC subtypes. In a total of 2,116 BCs, 91 ePVI-BCs, 70 inflammatory breast carcinomas (IBCs), and 114 casual BCs as a control group (CG-BC) were recruited.Results: Patients affected by ePVI-BC were younger, had larger tumors, higher histologic grade, elevated Ki-67 score, Her2/neu overexpressed, and more lymph node metastases compared with CG-BC (P <.001). Interestingly, only younger mean age at diagnosis differentiated patients with ePVI-BC from patients affected by IBC. ePVI-BC showed a clinical outcome intermediate between the prognoses of IBC and CG-BC.Conclusions: Results suggest that ePVI-BC and IBC may share some pathologic processes, providing a novel perspective on the heterogeneity of BC. Epidemiologic data and molecular studies on gene expression features are needed to rationally classify these tumors into their identified subtypes.
KW - Inflammatory breast carcinoma
KW - Invasive breast cancer
UR - http://www.scopus.com/inward/record.url?scp=84907171282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907171282&partnerID=8YFLogxK
U2 - 10.1309/AJCPOXKX67KRAOVM
DO - 10.1309/AJCPOXKX67KRAOVM
M3 - Article
C2 - 25125618
AN - SCOPUS:84907171282
VL - 142
SP - 299
EP - 306
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
SN - 0002-9173
IS - 3
ER -