Comparison between Invasive Breast Cancer with Extensive Peritumoral Vascular Invasion and Inflammatory Breast Carcinoma: A Clinicopathologic Study of 161 Cases

Erminia Manfrin, Andrea Remo, Massimo Pancione, Claudia Cannizzaro, Francesca Falsirollo, Giovanni Paolo Pollini, Francesca Pellini, Annamaria Molino, Matteo Brunelli, Roberto Vendraminelli, Michele Ceccarelli, Stefano Maria Pagnotta, Ines Simeone, Franco Bonetti

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives: Extensive peritumoral neoplastic lymphovascular invasion (ePVI) is a marker of aggressiveness in invasive breast carcinoma (BC).

Methods: We explored the impact of ePVI on different BC subtypes. In a total of 2,116 BCs, 91 ePVI-BCs, 70 inflammatory breast carcinomas (IBCs), and 114 casual BCs as a control group (CG-BC) were recruited.

Results: Patients affected by ePVI-BC were younger, had larger tumors, higher histologic grade, elevated Ki-67 score, Her2/neu overexpressed, and more lymph node metastases compared with CG-BC (P <.001). Interestingly, only younger mean age at diagnosis differentiated patients with ePVI-BC from patients affected by IBC. ePVI-BC showed a clinical outcome intermediate between the prognoses of IBC and CG-BC.

Conclusions: Results suggest that ePVI-BC and IBC may share some pathologic processes, providing a novel perspective on the heterogeneity of BC. Epidemiologic data and molecular studies on gene expression features are needed to rationally classify these tumors into their identified subtypes.

Original languageEnglish
Pages (from-to)299-306
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume142
Issue number3
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

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Inflammatory Breast Neoplasms
Blood Vessels
Breast Neoplasms
Pathologic Processes
Neoplasms
Lymph Nodes

Keywords

  • Inflammatory breast carcinoma
  • Invasive breast cancer

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Comparison between Invasive Breast Cancer with Extensive Peritumoral Vascular Invasion and Inflammatory Breast Carcinoma : A Clinicopathologic Study of 161 Cases. / Manfrin, Erminia; Remo, Andrea; Pancione, Massimo; Cannizzaro, Claudia; Falsirollo, Francesca; Pollini, Giovanni Paolo; Pellini, Francesca; Molino, Annamaria; Brunelli, Matteo; Vendraminelli, Roberto; Ceccarelli, Michele; Pagnotta, Stefano Maria; Simeone, Ines; Bonetti, Franco.

In: American Journal of Clinical Pathology, Vol. 142, No. 3, 01.01.2014, p. 299-306.

Research output: Contribution to journalArticle

Manfrin, E, Remo, A, Pancione, M, Cannizzaro, C, Falsirollo, F, Pollini, GP, Pellini, F, Molino, A, Brunelli, M, Vendraminelli, R, Ceccarelli, M, Pagnotta, SM, Simeone, I & Bonetti, F 2014, 'Comparison between Invasive Breast Cancer with Extensive Peritumoral Vascular Invasion and Inflammatory Breast Carcinoma: A Clinicopathologic Study of 161 Cases', American Journal of Clinical Pathology, vol. 142, no. 3, pp. 299-306. https://doi.org/10.1309/AJCPOXKX67KRAOVM
Manfrin, Erminia ; Remo, Andrea ; Pancione, Massimo ; Cannizzaro, Claudia ; Falsirollo, Francesca ; Pollini, Giovanni Paolo ; Pellini, Francesca ; Molino, Annamaria ; Brunelli, Matteo ; Vendraminelli, Roberto ; Ceccarelli, Michele ; Pagnotta, Stefano Maria ; Simeone, Ines ; Bonetti, Franco. / Comparison between Invasive Breast Cancer with Extensive Peritumoral Vascular Invasion and Inflammatory Breast Carcinoma : A Clinicopathologic Study of 161 Cases. In: American Journal of Clinical Pathology. 2014 ; Vol. 142, No. 3. pp. 299-306.
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