Comparison between GC-MS and GC-ICPMS using isotope dilution for the simultaneous monitoring of inorganic and methyl mercury, butyl and phenyl tin compounds in biological tissues

J. Cavalheiro, H. Preud'Homme, D. Amouroux, E. Tessier, M. Monperrus

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The aim of this work is to compare simultaneous isotope dilution analysis of organotin and organomercury compounds by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-inductively coupled plasma mass spectrometry (GC-ICP/MS) on certified bivalve samples. These samples were extracted by microwave with tetramethylammonium hydroxide (TMAH). Derivatization with both NaBEt4 and NaBPr4 was evaluated, and analytical performances were compared. Two CRM materials, BCR-710 and CRM-477, were analyzed by both techniques to verify accuracy. A mixed spike containing 201Hg-enriched methylmercury (MeHg), 199Hg-enriched inorganic mercury (iHg), 119Sn-enriched monobutyltin (MBT), dibutyltin (DBT), and tributyltin (TBT) as well as homemade 116Sn- enriched monophenyltin (MPT), diphenyltin (DPT), and triphenyltin (TPT) was used for the isotope dilution analysis of samples. The two techniques studied were compared in terms of classic analytical parameters: linearity, precision or repeatability (i.e., percent relative standard deviation, RSD%), limit of detection (LOD), and limit of quantification (LOQ), showing excellent linearity, precision below 12 % for all analytes, and LOQs of 0.06-1.45 pg for GC-MS and 0.02-0.27 pg for GC-ICP/MS. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1253-1258
Number of pages6
JournalAnalytical and Bioanalytical Chemistry
Volume406
Issue number4
DOIs
Publication statusPublished - 1 Feb 2014
Externally publishedYes

Fingerprint

Tin Compounds
Mercury
Isotopes
Gas chromatography
Gas Chromatography-Mass Spectrometry
Dilution
Mass spectrometry
Tissue
Inductively coupled plasma mass spectrometry
Organomercury Compounds
Monitoring
Mass Spectrometry
Organotin Compounds
Bivalvia
Microwaves
Gas Chromatography
Limit of Detection

Keywords

  • Biological tissues
  • GC-ICP/MS
  • GC-MS
  • Isotope dilution analysis
  • Organomercury
  • Organotin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Cite this

Comparison between GC-MS and GC-ICPMS using isotope dilution for the simultaneous monitoring of inorganic and methyl mercury, butyl and phenyl tin compounds in biological tissues. / Cavalheiro, J.; Preud'Homme, H.; Amouroux, D.; Tessier, E.; Monperrus, M.

In: Analytical and Bioanalytical Chemistry, Vol. 406, No. 4, 01.02.2014, p. 1253-1258.

Research output: Contribution to journalArticle

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AB - The aim of this work is to compare simultaneous isotope dilution analysis of organotin and organomercury compounds by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-inductively coupled plasma mass spectrometry (GC-ICP/MS) on certified bivalve samples. These samples were extracted by microwave with tetramethylammonium hydroxide (TMAH). Derivatization with both NaBEt4 and NaBPr4 was evaluated, and analytical performances were compared. Two CRM materials, BCR-710 and CRM-477, were analyzed by both techniques to verify accuracy. A mixed spike containing 201Hg-enriched methylmercury (MeHg), 199Hg-enriched inorganic mercury (iHg), 119Sn-enriched monobutyltin (MBT), dibutyltin (DBT), and tributyltin (TBT) as well as homemade 116Sn- enriched monophenyltin (MPT), diphenyltin (DPT), and triphenyltin (TPT) was used for the isotope dilution analysis of samples. The two techniques studied were compared in terms of classic analytical parameters: linearity, precision or repeatability (i.e., percent relative standard deviation, RSD%), limit of detection (LOD), and limit of quantification (LOQ), showing excellent linearity, precision below 12 % for all analytes, and LOQs of 0.06-1.45 pg for GC-MS and 0.02-0.27 pg for GC-ICP/MS. [Figure not available: see fulltext.]

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