Comparative evaluation of dynamic contrast-enhanced perfusion with diffusion tensor imaging metrics in assessment of corticospinal tract infiltration in malignant glioma

Rishi Awasthi, Sanjay Kumar Verma, Mohammad Haris, Anup Singh, Sanjay Behari, Awadhesh Kumar Jaiswal, Dinesh Rajput, Rakesh Pandey, Ram K S Rathore, Chandra M. Pandey, Rakesh K. Gupta

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To compare dynamic contrast-enhanced magnetic resonance imaging (DCE MRI) with diffusion tensor imaging (DTI) for predicting tumor infiltration in a conventional MRI normal-appearing internal capsule adjacent to the tumor in patients with glioblastoma multiforme. Methods: Thirty patients with glioblastoma multiforme underwent a neurological examination for motor assessment, DCE MRI, and DTI. On fused DCE and DTI images, regions of interest were placed on the normal-appearing internal capsule and the corresponding region of the contralateral internal capsule. These patients were pooled into group 1 (improved after surgery, n = 9) and group 2 (did not improve after surgery, n = 21) on the basis of motor strength. The DTI and perfusion metrics were statistically analyzed to look for a predictor of motor functionality. Results: Multivariate logistic regression analysis showed only cerebral blood volume to be the predictor of improvement in motor functionality after surgery (P = 0.043). Conclusions: We conclude that cerebral blood volume appears to be the predictor of motor functionality after surgery and may indirectly suggest tumor infiltration, whereas DTI helps to precisely localize the fiber tracts.

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume34
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

Fingerprint

Pyramidal Tracts
Diffusion Tensor Imaging
Glioma
Internal Capsule
Perfusion
Glioblastoma
Magnetic Resonance Imaging
Neoplasms
Neurologic Examination
Logistic Models
Regression Analysis

Keywords

  • Diffusion tensor imaging
  • Dynamic contrast-enhanced MRI
  • Glioblastoma multiforme
  • Internal capsule
  • Tumor infiltration

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Comparative evaluation of dynamic contrast-enhanced perfusion with diffusion tensor imaging metrics in assessment of corticospinal tract infiltration in malignant glioma. / Awasthi, Rishi; Verma, Sanjay Kumar; Haris, Mohammad; Singh, Anup; Behari, Sanjay; Jaiswal, Awadhesh Kumar; Rajput, Dinesh; Pandey, Rakesh; Rathore, Ram K S; Pandey, Chandra M.; Gupta, Rakesh K.

In: Journal of Computer Assisted Tomography, Vol. 34, No. 1, 01.2010, p. 82-88.

Research output: Contribution to journalArticle

Awasthi, Rishi ; Verma, Sanjay Kumar ; Haris, Mohammad ; Singh, Anup ; Behari, Sanjay ; Jaiswal, Awadhesh Kumar ; Rajput, Dinesh ; Pandey, Rakesh ; Rathore, Ram K S ; Pandey, Chandra M. ; Gupta, Rakesh K. / Comparative evaluation of dynamic contrast-enhanced perfusion with diffusion tensor imaging metrics in assessment of corticospinal tract infiltration in malignant glioma. In: Journal of Computer Assisted Tomography. 2010 ; Vol. 34, No. 1. pp. 82-88.
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