Combined analysis of genomewide scans for adult height: Results from the NHLBI family blood pressure program

Xiaodong Wu, Richard S. Cooper, Eric Boerwinkle, Stephen T. Turner, Steven Hunt, Richard Myers, Richard A. Olshen, David Curb, Xiaofeng Zhu, Donghui Kan, Amy Luke

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A combined analysis of genome scans was performed for adult height in the NHLBI Family Blood Pressure Program. Height data were available on 6752 individuals. Linkage analysis was performed first separately for each of the eight ethnic groups in the four networks using the variance component method. To increase the power to detect the common genetic components affecting height for all the individuals, a linkage analysis was performed subsequently for the combined data set by pooling the average allele-sharing IBD () for all groups. By combining the data, we replicated evidence for a QTL influencing adult height on chromosome 7 (7q31) (LOD=2.46), which has been reported in two previous studies. Suggestive linkage (LOD>1) was found in another six regions in our combined analysis. Evidence for linkage for two of these regions (2p12, 20p11) has also been reported previously.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalEuropean Journal of Human Genetics
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Mar 2003
Externally publishedYes

Fingerprint

National Heart, Lung, and Blood Institute (U.S.)
Chromosomes, Human, Pair 7
Ethnic Groups
Meta-Analysis
Alleles
Genome
Blood Pressure
Power (Psychology)
Datasets

Keywords

  • BMI
  • Genome scan
  • Height
  • Linkage

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Combined analysis of genomewide scans for adult height : Results from the NHLBI family blood pressure program. / Wu, Xiaodong; Cooper, Richard S.; Boerwinkle, Eric; Turner, Stephen T.; Hunt, Steven; Myers, Richard; Olshen, Richard A.; Curb, David; Zhu, Xiaofeng; Kan, Donghui; Luke, Amy.

In: European Journal of Human Genetics, Vol. 11, No. 3, 01.03.2003, p. 271-274.

Research output: Contribution to journalArticle

Wu, X, Cooper, RS, Boerwinkle, E, Turner, ST, Hunt, S, Myers, R, Olshen, RA, Curb, D, Zhu, X, Kan, D & Luke, A 2003, 'Combined analysis of genomewide scans for adult height: Results from the NHLBI family blood pressure program', European Journal of Human Genetics, vol. 11, no. 3, pp. 271-274. https://doi.org/10.1038/sj.ejhg.5200952
Wu, Xiaodong ; Cooper, Richard S. ; Boerwinkle, Eric ; Turner, Stephen T. ; Hunt, Steven ; Myers, Richard ; Olshen, Richard A. ; Curb, David ; Zhu, Xiaofeng ; Kan, Donghui ; Luke, Amy. / Combined analysis of genomewide scans for adult height : Results from the NHLBI family blood pressure program. In: European Journal of Human Genetics. 2003 ; Vol. 11, No. 3. pp. 271-274.
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