Collagenase in Idiopathic Pulmonary Fibrosis

Thomas K. Hunt, James E. Gadek, Gerald A. Fells, Ronald G. Crystal, Herbert Y. Reynolds

Research output: Contribution to journalLetter


To the Editor: In the October 4 issue, Gadek and his associates compared patients who had idiopathic pulmonary fibrosis with normal subjects and patients who had sarcoidosis as controls. Collagenolytic and neutral protease levels in bronchial aspirates were elevated in patients with idiopathic pulmonary fibrosis. Their conclusion that collagenase is specific for idiopathic pulmonary fibrosis and is not a universal phenomenon in all chronic inflammatory lung disorders seems an exaggeration since what they actually proved is that the exudate of alveolitis in idiopathic pulmonary fibrosis contains more collagenase than does fluid from the respiratory tracts of patients with sarcoidosis. The.

Original languageEnglish
Pages (from-to)810-811
Number of pages2
JournalNew England Journal of Medicine
Issue number14
Publication statusPublished - 3 Apr 1980


ASJC Scopus subject areas

  • Medicine(all)

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