Collagen in the lung: development of a technology applicable to human lung disease

R. G. Crystal, K. H. Bradley, S. D. McConnell-Breu, J. F. Collins, A. J. Hanca, M. J. Cowan

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Abstract

Techniques have been developed to quantitate in vitro the types, rates and fates of collagen synthesized by animal and human lung. Studies are continuing to apply these techniques to investigate important lung disorders, including classification of the fibrotic lung disorders by the types of collagen synthesized; development of an in vitro drug evaluation system to determine in a lung biopsy, which drugs are useful in reducing the fibrotic process for a patient with interstitial disease; and investigations of the influence of serum proteins on lung connective tissue synthesis and proteolysis.

Original languageEnglish
Pages (from-to)30S-31S
JournalCHEST
Volume67
Issue number2 Sup.
Publication statusPublished - 1 Dec 1975

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Crystal, R. G., Bradley, K. H., McConnell-Breu, S. D., Collins, J. F., Hanca, A. J., & Cowan, M. J. (1975). Collagen in the lung: development of a technology applicable to human lung disease. CHEST, 67(2 Sup.), 30S-31S.