Cognitive reserve and neuropsychological functioning in patients infected with hepatitis C

Linas A. Bieliauskas, Carla Back-Madruga, Karen L. Lindsay, Elizabeth C. Wright, Ziad Kronfol, Anna S F Lok, Robert J. Fontana

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16 Citations (Scopus)


This study evaluated the influence of cognitive reserve on neuropsychological test performance in 198 patients infected with the hepatitis C virus. IQ scores, educational level, and occupational rating were combined to calculate a Cognitive Reserve Score (CRS) for each patient. Similar to studies of infection with the human immunodeficiency virus, there was a significantly increased risk of impairment in neuropsychological test performance in individuals with lower CRSs. It is important to account for CRS when assessing cognitive findings in large-scale clinical trials.

Original languageEnglish
Pages (from-to)687-692
Number of pages6
JournalJournal of the International Neuropsychological Society
Issue number4
Publication statusPublished - Jul 2007
Externally publishedYes



  • Cognitive manifestations
  • Hepatic insufficiency
  • Intelligence
  • IQ
  • Liver diseases
  • Neurobehavioral manifestations

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Psychology(all)

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