Cocaine induced supersensitivity in the human umbilical artery

R. J. Reiffenstein, Christopher Triggle

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Cocaine (3.3 x 10-7 - 3.3 x 10-5 M) has no effect on the uptake of noradrenaline by the smooth muscle cells of the human umbilical artery but was found to potentiate the mean effective dose (ED50) responses of isolated helical strips of human umbilical artery to noradrenaline (3 x 10-5 M), and, to a lesser degree, serotonin (3.65 x 10-4 M), but had no effect on the response to KCl (40 mM) or histamine (1.8 x 10-6 M). Concentrations of cocaine above 1.7 x 10-4 M were found to antagonize ED50 responses to all the agonists tested. Because the preparation used in these studies does not receive sympathetic innervation, the effect of cocaine is likely to be mediated by an action at the level of the muscle. This selective increase in the response mediated by noradrenaline may be explained by an allosteric alteration of the α adrenergic receptor system and/or a semiselective increase in smooth muscle sensitivity.

Original languageEnglish
Pages (from-to)687-698
Number of pages12
JournalCanadian Journal of Physiology and Pharmacology
Volume52
Issue number3
Publication statusPublished - 1974
Externally publishedYes

Fingerprint

Umbilical Arteries
Cocaine
Norepinephrine
Adrenergic Receptors
Histamine
Smooth Muscle Myocytes
Smooth Muscle
Serotonin
Muscles

ASJC Scopus subject areas

  • Physiology
  • Pharmacology

Cite this

Cocaine induced supersensitivity in the human umbilical artery. / Reiffenstein, R. J.; Triggle, Christopher.

In: Canadian Journal of Physiology and Pharmacology, Vol. 52, No. 3, 1974, p. 687-698.

Research output: Contribution to journalArticle

@article{61c3e251f20e444883766c80240d043f,
title = "Cocaine induced supersensitivity in the human umbilical artery",
abstract = "Cocaine (3.3 x 10-7 - 3.3 x 10-5 M) has no effect on the uptake of noradrenaline by the smooth muscle cells of the human umbilical artery but was found to potentiate the mean effective dose (ED50) responses of isolated helical strips of human umbilical artery to noradrenaline (3 x 10-5 M), and, to a lesser degree, serotonin (3.65 x 10-4 M), but had no effect on the response to KCl (40 mM) or histamine (1.8 x 10-6 M). Concentrations of cocaine above 1.7 x 10-4 M were found to antagonize ED50 responses to all the agonists tested. Because the preparation used in these studies does not receive sympathetic innervation, the effect of cocaine is likely to be mediated by an action at the level of the muscle. This selective increase in the response mediated by noradrenaline may be explained by an allosteric alteration of the α adrenergic receptor system and/or a semiselective increase in smooth muscle sensitivity.",
author = "Reiffenstein, {R. J.} and Christopher Triggle",
year = "1974",
language = "English",
volume = "52",
pages = "687--698",
journal = "Canadian Journal of Physiology and Pharmacology",
issn = "0008-4212",
publisher = "National Research Council of Canada",
number = "3",

}

TY - JOUR

T1 - Cocaine induced supersensitivity in the human umbilical artery

AU - Reiffenstein, R. J.

AU - Triggle, Christopher

PY - 1974

Y1 - 1974

N2 - Cocaine (3.3 x 10-7 - 3.3 x 10-5 M) has no effect on the uptake of noradrenaline by the smooth muscle cells of the human umbilical artery but was found to potentiate the mean effective dose (ED50) responses of isolated helical strips of human umbilical artery to noradrenaline (3 x 10-5 M), and, to a lesser degree, serotonin (3.65 x 10-4 M), but had no effect on the response to KCl (40 mM) or histamine (1.8 x 10-6 M). Concentrations of cocaine above 1.7 x 10-4 M were found to antagonize ED50 responses to all the agonists tested. Because the preparation used in these studies does not receive sympathetic innervation, the effect of cocaine is likely to be mediated by an action at the level of the muscle. This selective increase in the response mediated by noradrenaline may be explained by an allosteric alteration of the α adrenergic receptor system and/or a semiselective increase in smooth muscle sensitivity.

AB - Cocaine (3.3 x 10-7 - 3.3 x 10-5 M) has no effect on the uptake of noradrenaline by the smooth muscle cells of the human umbilical artery but was found to potentiate the mean effective dose (ED50) responses of isolated helical strips of human umbilical artery to noradrenaline (3 x 10-5 M), and, to a lesser degree, serotonin (3.65 x 10-4 M), but had no effect on the response to KCl (40 mM) or histamine (1.8 x 10-6 M). Concentrations of cocaine above 1.7 x 10-4 M were found to antagonize ED50 responses to all the agonists tested. Because the preparation used in these studies does not receive sympathetic innervation, the effect of cocaine is likely to be mediated by an action at the level of the muscle. This selective increase in the response mediated by noradrenaline may be explained by an allosteric alteration of the α adrenergic receptor system and/or a semiselective increase in smooth muscle sensitivity.

UR - http://www.scopus.com/inward/record.url?scp=0016158857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016158857&partnerID=8YFLogxK

M3 - Article

C2 - 4851065

AN - SCOPUS:0016158857

VL - 52

SP - 687

EP - 698

JO - Canadian Journal of Physiology and Pharmacology

JF - Canadian Journal of Physiology and Pharmacology

SN - 0008-4212

IS - 3

ER -