Cloning of S4D-SRCRB, a new soluble member of the group B scavenger receptor cysteine-rich family (SRCR-SF) mapping to human chromosome 7q11.23

Olga Padilla, Miguel Angel Pujana, Agustí López-de la Iglesia, Idoia Gimferrer, Mònica Arman, Josep Maria Vilá, Lourdes Places, Jordi Vives, Xavier Estivill, Francisco Lozano

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9 Citations (Scopus)


The scavenger receptor cysteine-rich superfamily (SRCR-SF) is a highly conserved group of membrane and/or secreted proteins related to the innate and adaptive immune system. Here, we report the cloning of the gene encoding human S4D-SRCRB, a novel soluble member of the SRCR-SF, which is composed of four group B SRCR domains separated by Pro-, Ser- and Thr-rich polypeptides. The longest cDNA sequence found is 2,806 bp in length and encodes a mature protein of 528 aa, with a predicted molecular mass of Mr 55,600. The S4D-SRCRB gene is located at Chromosome 7q11.23, telomeric to the Williams-Beuren syndrome deletion. It extends over 20 kb and consists of 11 exons, with each SRCR domain being encoded by a single exon. Northern blot analysis indicated that S4D-SRCRB has a broad tissue distribution and is expressed as two major mRNA species: one of 2.8 kb, with a restricted tissue expression pattern (mainly kidney and placenta), and another of 1.5 kb, with a broader distribution. A similar mRNA expression pattern was observed during the analysis of several tumor cell lines. The highest degree of similarity found between S4D-SRCRB and other group B SRCR-SF members was with human DMBT1 (a mosaic protein composed of fourteen SRCR domains, which is involved in innate defense and epithelia polarization) and chicken 18-B (a turpentine-induced soluble acute-phase protein composed of four SRCR domains). Our data indicate that S4D-SRCRB constitutes a novel SRCR-SF member, which could be involved in basic homeostatic functions such as innate host defense.

Original languageEnglish
Pages (from-to)621-634
Number of pages14
Issue number9
Publication statusPublished - 24 Dec 2002



  • Human Chromosome 7q11.23
  • Innate defense
  • SRCR superfamily
  • Williams-Beuren syndrome deletion

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Padilla, O., Pujana, M. A., López-de la Iglesia, A., Gimferrer, I., Arman, M., Vilá, J. M., Places, L., Vives, J., Estivill, X., & Lozano, F. (2002). Cloning of S4D-SRCRB, a new soluble member of the group B scavenger receptor cysteine-rich family (SRCR-SF) mapping to human chromosome 7q11.23. Immunogenetics, 54(9), 621-634.