Clonality of slime-producing methicillin-resistant coagulase-negative staphylococci disseminated in the neonatal intensive care unit of a university hospital

A. Foka, V. Chini, E. Petinaki, F. Kolonitsiou, E. D. Anastassiou, G. Dimitracopoulos, I. Spiliopoulou

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Methicillin-resistant coagulase-negative staphylococci (MR-CNS) (n = 132), isolated from pre-term neonates, were analysed to determine their antibiotic resistance patterns, clonal distribution, biofilm production and the presence of the ica operon. All MR-CNS were multiresistant, and 89% produced slime. A major clone was identified (77 isolates) among 115 Staphylococcus epidermidis isolates. Ten of 16 Staphylococcus haemolyticus isolates also belonged to a single clone. Most (80%) slime-positive isolates possessed all the ica genes tested, while the remaining 23 (20%) had a variety of gene combinations. The entire ica cluster was detected in three of 15 slime-negative isolates. One major and two minor slime-positive, multiresistant MR-CNS clones had disseminated among hospitalised pre-term neonates.

Original languageEnglish
Pages (from-to)1230-1233
Number of pages4
JournalClinical Microbiology and Infection
Issue number12
Publication statusPublished - Dec 2006



  • Coagulase-negative staphylococci
  • Epidemiology
  • Ica gene cluster
  • Neonates
  • Slime production
  • Typing

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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