Clonality of slime-producing methicillin-resistant coagulase-negative staphylococci disseminated in the neonatal intensive care unit of a university hospital

A. Foka, V. Chini, E. Petinaki, F. Kolonitsiou, E. D. Anastassiou, G. Dimitracopoulos, I. Spiliopoulou

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Methicillin-resistant coagulase-negative staphylococci (MR-CNS) (n = 132), isolated from pre-term neonates, were analysed to determine their antibiotic resistance patterns, clonal distribution, biofilm production and the presence of the ica operon. All MR-CNS were multiresistant, and 89% produced slime. A major clone was identified (77 isolates) among 115 Staphylococcus epidermidis isolates. Ten of 16 Staphylococcus haemolyticus isolates also belonged to a single clone. Most (80%) slime-positive isolates possessed all the ica genes tested, while the remaining 23 (20%) had a variety of gene combinations. The entire ica cluster was detected in three of 15 slime-negative isolates. One major and two minor slime-positive, multiresistant MR-CNS clones had disseminated among hospitalised pre-term neonates.

Original languageEnglish
Pages (from-to)1230-1233
Number of pages4
JournalClinical Microbiology and Infection
Volume12
Issue number12
DOIs
Publication statusPublished - Dec 2006
Externally publishedYes

Fingerprint

Methicillin Resistance
Coagulase
Neonatal Intensive Care Units
Staphylococcus
Clone Cells
Staphylococcus haemolyticus
Staphylococcus epidermidis
Operon
Biofilms
Microbial Drug Resistance
Genes

Keywords

  • Coagulase-negative staphylococci
  • Epidemiology
  • Ica gene cluster
  • Neonates
  • Slime production
  • Typing

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

Cite this

Clonality of slime-producing methicillin-resistant coagulase-negative staphylococci disseminated in the neonatal intensive care unit of a university hospital. / Foka, A.; Chini, V.; Petinaki, E.; Kolonitsiou, F.; Anastassiou, E. D.; Dimitracopoulos, G.; Spiliopoulou, I.

In: Clinical Microbiology and Infection, Vol. 12, No. 12, 12.2006, p. 1230-1233.

Research output: Contribution to journalArticle

Foka, A. ; Chini, V. ; Petinaki, E. ; Kolonitsiou, F. ; Anastassiou, E. D. ; Dimitracopoulos, G. ; Spiliopoulou, I. / Clonality of slime-producing methicillin-resistant coagulase-negative staphylococci disseminated in the neonatal intensive care unit of a university hospital. In: Clinical Microbiology and Infection. 2006 ; Vol. 12, No. 12. pp. 1230-1233.
@article{d133023b063d48b3ab9a601093809c22,
title = "Clonality of slime-producing methicillin-resistant coagulase-negative staphylococci disseminated in the neonatal intensive care unit of a university hospital",
abstract = "Methicillin-resistant coagulase-negative staphylococci (MR-CNS) (n = 132), isolated from pre-term neonates, were analysed to determine their antibiotic resistance patterns, clonal distribution, biofilm production and the presence of the ica operon. All MR-CNS were multiresistant, and 89{\%} produced slime. A major clone was identified (77 isolates) among 115 Staphylococcus epidermidis isolates. Ten of 16 Staphylococcus haemolyticus isolates also belonged to a single clone. Most (80{\%}) slime-positive isolates possessed all the ica genes tested, while the remaining 23 (20{\%}) had a variety of gene combinations. The entire ica cluster was detected in three of 15 slime-negative isolates. One major and two minor slime-positive, multiresistant MR-CNS clones had disseminated among hospitalised pre-term neonates.",
keywords = "Coagulase-negative staphylococci, Epidemiology, Ica gene cluster, Neonates, Slime production, Typing",
author = "A. Foka and V. Chini and E. Petinaki and F. Kolonitsiou and Anastassiou, {E. D.} and G. Dimitracopoulos and I. Spiliopoulou",
year = "2006",
month = "12",
doi = "10.1111/j.1469-0691.2006.01565.x",
language = "English",
volume = "12",
pages = "1230--1233",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier Limited",
number = "12",

}

TY - JOUR

T1 - Clonality of slime-producing methicillin-resistant coagulase-negative staphylococci disseminated in the neonatal intensive care unit of a university hospital

AU - Foka, A.

AU - Chini, V.

AU - Petinaki, E.

AU - Kolonitsiou, F.

AU - Anastassiou, E. D.

AU - Dimitracopoulos, G.

AU - Spiliopoulou, I.

PY - 2006/12

Y1 - 2006/12

N2 - Methicillin-resistant coagulase-negative staphylococci (MR-CNS) (n = 132), isolated from pre-term neonates, were analysed to determine their antibiotic resistance patterns, clonal distribution, biofilm production and the presence of the ica operon. All MR-CNS were multiresistant, and 89% produced slime. A major clone was identified (77 isolates) among 115 Staphylococcus epidermidis isolates. Ten of 16 Staphylococcus haemolyticus isolates also belonged to a single clone. Most (80%) slime-positive isolates possessed all the ica genes tested, while the remaining 23 (20%) had a variety of gene combinations. The entire ica cluster was detected in three of 15 slime-negative isolates. One major and two minor slime-positive, multiresistant MR-CNS clones had disseminated among hospitalised pre-term neonates.

AB - Methicillin-resistant coagulase-negative staphylococci (MR-CNS) (n = 132), isolated from pre-term neonates, were analysed to determine their antibiotic resistance patterns, clonal distribution, biofilm production and the presence of the ica operon. All MR-CNS were multiresistant, and 89% produced slime. A major clone was identified (77 isolates) among 115 Staphylococcus epidermidis isolates. Ten of 16 Staphylococcus haemolyticus isolates also belonged to a single clone. Most (80%) slime-positive isolates possessed all the ica genes tested, while the remaining 23 (20%) had a variety of gene combinations. The entire ica cluster was detected in three of 15 slime-negative isolates. One major and two minor slime-positive, multiresistant MR-CNS clones had disseminated among hospitalised pre-term neonates.

KW - Coagulase-negative staphylococci

KW - Epidemiology

KW - Ica gene cluster

KW - Neonates

KW - Slime production

KW - Typing

UR - http://www.scopus.com/inward/record.url?scp=33751081017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751081017&partnerID=8YFLogxK

U2 - 10.1111/j.1469-0691.2006.01565.x

DO - 10.1111/j.1469-0691.2006.01565.x

M3 - Article

VL - 12

SP - 1230

EP - 1233

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 12

ER -