Clonal persistence and evolution during a decade of recurrent melanoma

Ena Wang, Sonia Voiculescu, Isabelle C. Le Poole, Mona El-Gamil, Xin Li, Marianna Sabatino, Paul F. Robbins, Brian J. Nickoloff, Francesco M. Marincola

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

A patient with metastatic cutaneous melanoma responsive to immunotherapy experienced several recurrences over a decade of observation. With each recurrence, biopsies were obtained and cell lines generated. A rare mutation of the Β-catenin gene and an unbalanced methylation of the androgen receptor were documented in all cell lines. Karyotyping and comparative genomic hybridization identified consistent genetic traits in spite of divergent phenotypes, suggesting that all the metastases were derived from the same primary tumor, although they were each probably not derived from the most recent previous metastasis in a sequential manner. Thus, metastatic melanoma recurs from a common progenitor cell and phenotypic changes occur around a central core of genetic stability. This observation may bear significance for the development of targeted anticancer therapies.

Original languageEnglish
Pages (from-to)1372-1377
Number of pages6
JournalJournal of Investigative Dermatology
Volume126
Issue number6
DOIs
Publication statusPublished - Jun 2006
Externally publishedYes

Fingerprint

Clonal Evolution
Melanoma
Cells
Neoplasm Metastasis
Recurrence
Cell Line
Catenins
Karyotyping
Methylation
Comparative Genomic Hybridization
Biopsy
Androgen Receptors
Immunotherapy
Tumors
Stem Cells
Genes
Observation
Phenotype
Skin
Mutation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Wang, E., Voiculescu, S., Le Poole, I. C., El-Gamil, M., Li, X., Sabatino, M., ... Marincola, F. M. (2006). Clonal persistence and evolution during a decade of recurrent melanoma. Journal of Investigative Dermatology, 126(6), 1372-1377. https://doi.org/10.1038/sj.jid.5700193

Clonal persistence and evolution during a decade of recurrent melanoma. / Wang, Ena; Voiculescu, Sonia; Le Poole, Isabelle C.; El-Gamil, Mona; Li, Xin; Sabatino, Marianna; Robbins, Paul F.; Nickoloff, Brian J.; Marincola, Francesco M.

In: Journal of Investigative Dermatology, Vol. 126, No. 6, 06.2006, p. 1372-1377.

Research output: Contribution to journalArticle

Wang, E, Voiculescu, S, Le Poole, IC, El-Gamil, M, Li, X, Sabatino, M, Robbins, PF, Nickoloff, BJ & Marincola, FM 2006, 'Clonal persistence and evolution during a decade of recurrent melanoma', Journal of Investigative Dermatology, vol. 126, no. 6, pp. 1372-1377. https://doi.org/10.1038/sj.jid.5700193
Wang, Ena ; Voiculescu, Sonia ; Le Poole, Isabelle C. ; El-Gamil, Mona ; Li, Xin ; Sabatino, Marianna ; Robbins, Paul F. ; Nickoloff, Brian J. ; Marincola, Francesco M. / Clonal persistence and evolution during a decade of recurrent melanoma. In: Journal of Investigative Dermatology. 2006 ; Vol. 126, No. 6. pp. 1372-1377.
@article{6251dd74c7d247ed8ab8c3d2675c6cbe,
title = "Clonal persistence and evolution during a decade of recurrent melanoma",
abstract = "A patient with metastatic cutaneous melanoma responsive to immunotherapy experienced several recurrences over a decade of observation. With each recurrence, biopsies were obtained and cell lines generated. A rare mutation of the Β-catenin gene and an unbalanced methylation of the androgen receptor were documented in all cell lines. Karyotyping and comparative genomic hybridization identified consistent genetic traits in spite of divergent phenotypes, suggesting that all the metastases were derived from the same primary tumor, although they were each probably not derived from the most recent previous metastasis in a sequential manner. Thus, metastatic melanoma recurs from a common progenitor cell and phenotypic changes occur around a central core of genetic stability. This observation may bear significance for the development of targeted anticancer therapies.",
author = "Ena Wang and Sonia Voiculescu and {Le Poole}, {Isabelle C.} and Mona El-Gamil and Xin Li and Marianna Sabatino and Robbins, {Paul F.} and Nickoloff, {Brian J.} and Marincola, {Francesco M.}",
year = "2006",
month = "6",
doi = "10.1038/sj.jid.5700193",
language = "English",
volume = "126",
pages = "1372--1377",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Clonal persistence and evolution during a decade of recurrent melanoma

AU - Wang, Ena

AU - Voiculescu, Sonia

AU - Le Poole, Isabelle C.

AU - El-Gamil, Mona

AU - Li, Xin

AU - Sabatino, Marianna

AU - Robbins, Paul F.

AU - Nickoloff, Brian J.

AU - Marincola, Francesco M.

PY - 2006/6

Y1 - 2006/6

N2 - A patient with metastatic cutaneous melanoma responsive to immunotherapy experienced several recurrences over a decade of observation. With each recurrence, biopsies were obtained and cell lines generated. A rare mutation of the Β-catenin gene and an unbalanced methylation of the androgen receptor were documented in all cell lines. Karyotyping and comparative genomic hybridization identified consistent genetic traits in spite of divergent phenotypes, suggesting that all the metastases were derived from the same primary tumor, although they were each probably not derived from the most recent previous metastasis in a sequential manner. Thus, metastatic melanoma recurs from a common progenitor cell and phenotypic changes occur around a central core of genetic stability. This observation may bear significance for the development of targeted anticancer therapies.

AB - A patient with metastatic cutaneous melanoma responsive to immunotherapy experienced several recurrences over a decade of observation. With each recurrence, biopsies were obtained and cell lines generated. A rare mutation of the Β-catenin gene and an unbalanced methylation of the androgen receptor were documented in all cell lines. Karyotyping and comparative genomic hybridization identified consistent genetic traits in spite of divergent phenotypes, suggesting that all the metastases were derived from the same primary tumor, although they were each probably not derived from the most recent previous metastasis in a sequential manner. Thus, metastatic melanoma recurs from a common progenitor cell and phenotypic changes occur around a central core of genetic stability. This observation may bear significance for the development of targeted anticancer therapies.

UR - http://www.scopus.com/inward/record.url?scp=33745517244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745517244&partnerID=8YFLogxK

U2 - 10.1038/sj.jid.5700193

DO - 10.1038/sj.jid.5700193

M3 - Article

VL - 126

SP - 1372

EP - 1377

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 6

ER -