Clinicopathological features of inflammatory versus noninflammatory locally advanced nonmetastatic breast cancer

B. Brouwers, R. Paridaens, J. P. Lobelle, Wouter R. Hendrickx, A. Smeets, P. Neven, C. Weltens, K. Deraedt, I. Vanden Bempt, M. R. Christiaens, H. Wildiers

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Inflammatory breast cancer (IBC) is a rare but aggressive form of breast cancer. It is mainly a clinical diagnosis. The aim of this study was to compare IBC to clinically diagnosed noninflammatory locally advanced nonmetastatic breast cancer, also called cLABC. Material and Methods: One hundred and eight patients were studied: 49 with IBC and 59 with cLABC. The following features were analyzed: age at diagnosis, body mass index (BMI), axillary lymph node status (cN), estrogen receptor status (ER), progesterone receptor status (PR), HER2 status, histological tumor grade and subtype. Short-term disease-free (DFS) and overall survival (OS) were also assessed in both groups. Results: Compared with cLABC, IBC was less often PR positive (41.7 vs. 66.1%, p = 0.01) and showed a trend to be more often HER2 positive (34.7 vs. 19.3%, p = 0.07). The 3-year DFS was 63 and 77%, respectively, for IBC and cLABC (p = 0.01); these figures were 83 and 85% for OS (p = 0.17). No significant differences in age at diagnosis, ER, cN, BMI, histological tumor grade or subtype were demonstrated. Conclusion: Compared to cLABC, IBC are more frequently PR negative, have a worse DFS, and have a tendency to be more often HER2 positive. These data reinforce the idea of IBC being a distinct biological entity compared to noninflammatory breast cancer.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalTumor Biology
Volume29
Issue number4
DOIs
Publication statusPublished - 1 Sep 2008
Externally publishedYes

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Inflammatory Breast Neoplasms
Breast Neoplasms
Progesterone Receptors
Estrogen Receptors
Body Mass Index
Survival
Neoplasms
Lymph Nodes

Keywords

  • Breast cancer, inflammatory
  • Breast cancer, locally advanced
  • HER2

ASJC Scopus subject areas

  • Cancer Research

Cite this

Clinicopathological features of inflammatory versus noninflammatory locally advanced nonmetastatic breast cancer. / Brouwers, B.; Paridaens, R.; Lobelle, J. P.; Hendrickx, Wouter R.; Smeets, A.; Neven, P.; Weltens, C.; Deraedt, K.; Vanden Bempt, I.; Christiaens, M. R.; Wildiers, H.

In: Tumor Biology, Vol. 29, No. 4, 01.09.2008, p. 211-216.

Research output: Contribution to journalArticle

Brouwers, B, Paridaens, R, Lobelle, JP, Hendrickx, WR, Smeets, A, Neven, P, Weltens, C, Deraedt, K, Vanden Bempt, I, Christiaens, MR & Wildiers, H 2008, 'Clinicopathological features of inflammatory versus noninflammatory locally advanced nonmetastatic breast cancer', Tumor Biology, vol. 29, no. 4, pp. 211-216. https://doi.org/10.1159/000152938
Brouwers, B. ; Paridaens, R. ; Lobelle, J. P. ; Hendrickx, Wouter R. ; Smeets, A. ; Neven, P. ; Weltens, C. ; Deraedt, K. ; Vanden Bempt, I. ; Christiaens, M. R. ; Wildiers, H. / Clinicopathological features of inflammatory versus noninflammatory locally advanced nonmetastatic breast cancer. In: Tumor Biology. 2008 ; Vol. 29, No. 4. pp. 211-216.
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AU - Neven, P.

AU - Weltens, C.

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N2 - Background: Inflammatory breast cancer (IBC) is a rare but aggressive form of breast cancer. It is mainly a clinical diagnosis. The aim of this study was to compare IBC to clinically diagnosed noninflammatory locally advanced nonmetastatic breast cancer, also called cLABC. Material and Methods: One hundred and eight patients were studied: 49 with IBC and 59 with cLABC. The following features were analyzed: age at diagnosis, body mass index (BMI), axillary lymph node status (cN), estrogen receptor status (ER), progesterone receptor status (PR), HER2 status, histological tumor grade and subtype. Short-term disease-free (DFS) and overall survival (OS) were also assessed in both groups. Results: Compared with cLABC, IBC was less often PR positive (41.7 vs. 66.1%, p = 0.01) and showed a trend to be more often HER2 positive (34.7 vs. 19.3%, p = 0.07). The 3-year DFS was 63 and 77%, respectively, for IBC and cLABC (p = 0.01); these figures were 83 and 85% for OS (p = 0.17). No significant differences in age at diagnosis, ER, cN, BMI, histological tumor grade or subtype were demonstrated. Conclusion: Compared to cLABC, IBC are more frequently PR negative, have a worse DFS, and have a tendency to be more often HER2 positive. These data reinforce the idea of IBC being a distinct biological entity compared to noninflammatory breast cancer.

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