Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy

K. I. Khawaja, D. Walker, S. A. Hayat, A. J.M. Boulton, Rayaz A. Malik

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8 Citations (Scopus)

Abstract

We report the clinico-pathological features and management of a 49-year- old male with a 30-year history of Type 1 diabetes mellitus who had nephropathy (proteinuria 1.81 g/24 h, creatinine 136 μmol/l), proliferative retinopathy and severe somatic and autonomic neuropathy. A sural nerve biopsy demonstrated marked myelinated fibre loss with unmyelinated fibre degeneration and regeneration combined with extensive endoneurial microangiopathy. The management of the patient's blood pressure problems (supine hypertension) and symptomatic postural hypotension is discussed.

Original languageEnglish
Pages (from-to)163-166
Number of pages4
JournalDiabetic Medicine
Volume17
Issue number2
DOIs
Publication statusPublished - 30 Mar 2000

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Keywords

  • Autonomic
  • Capillary
  • Diabetes
  • Nerve fibre
  • Neuropathy
  • Postural hypotension

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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