We report the clinico-pathological features and management of a 49-year- old male with a 30-year history of Type 1 diabetes mellitus who had nephropathy (proteinuria 1.81 g/24 h, creatinine 136 μmol/l), proliferative retinopathy and severe somatic and autonomic neuropathy. A sural nerve biopsy demonstrated marked myelinated fibre loss with unmyelinated fibre degeneration and regeneration combined with extensive endoneurial microangiopathy. The management of the patient's blood pressure problems (supine hypertension) and symptomatic postural hypotension is discussed.
- Nerve fibre
- Postural hypotension
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism