Clinical relevance of cognitive scores in hepatitis C patients with advanced fibrosis

Linas A. Bieliauskas, Carla Back-Madruga, Karen L. Lindsay, Kristin K. Snow, Ziad Kronfol, Anna S. Lok, Latha Padmanabhan, Robert J. Fontana

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Mild neuropsychological impairment has previously been reported in chronic hepatitis C (CHC) patients. The aim of this study was to assess the presence and severity of cognitive impairment among a cohort of CHC patients with advanced fibrosis using clinician ratings compared to classification based upon statistical methods. In addition, we set out to determine the relationship between cognitive scores and functional status. Two experienced neuropsychologists provided "clinician ratings" on a battery of 10 neuropsychological tests performed in 100 randomly selected patients participating in the HALT-C clinical trial. The overall kappa between the 2 graders on level of impairment was 0.59. Clinician ratings (the gold standard) were similarly sensitive to identifying cognitive impairment as was classification based on standard scores (44% vs. 40%). Global Deficit Scores (GDS), derived from pooling standard scores, also identified 44% of patients as having mild impairment and were highly correlated with clinician ratings (r = .81 p = < 0.0001). Neither clinician ratings nor deficit scores correlated with SF-36 subscale or summary scores but did correlate with depression scores (p < .0007). In summary, clinician ratings and deficit scores identified a similar prevalence of cognitive impairment amongst CHC patients with advanced fibrosis. There was a significant correlation between cognitive impairment and self-reported depression.

Original languageEnglish
Pages (from-to)1346-1361
Number of pages16
JournalJournal of Clinical and Experimental Neuropsychology
Volume28
Issue number8
DOIs
Publication statusPublished - 1 Dec 2006
Externally publishedYes

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Hepatitis C
Fibrosis
Chronic Hepatitis C
Depression
Neuropsychological Tests
Clinical Trials
Cognitive Dysfunction

ASJC Scopus subject areas

  • Clinical Psychology
  • Neurology
  • Clinical Neurology

Cite this

Bieliauskas, L. A., Back-Madruga, C., Lindsay, K. L., Snow, K. K., Kronfol, Z., Lok, A. S., ... Fontana, R. J. (2006). Clinical relevance of cognitive scores in hepatitis C patients with advanced fibrosis. Journal of Clinical and Experimental Neuropsychology, 28(8), 1346-1361. https://doi.org/10.1080/13803390500473720

Clinical relevance of cognitive scores in hepatitis C patients with advanced fibrosis. / Bieliauskas, Linas A.; Back-Madruga, Carla; Lindsay, Karen L.; Snow, Kristin K.; Kronfol, Ziad; Lok, Anna S.; Padmanabhan, Latha; Fontana, Robert J.

In: Journal of Clinical and Experimental Neuropsychology, Vol. 28, No. 8, 01.12.2006, p. 1346-1361.

Research output: Contribution to journalArticle

Bieliauskas, LA, Back-Madruga, C, Lindsay, KL, Snow, KK, Kronfol, Z, Lok, AS, Padmanabhan, L & Fontana, RJ 2006, 'Clinical relevance of cognitive scores in hepatitis C patients with advanced fibrosis', Journal of Clinical and Experimental Neuropsychology, vol. 28, no. 8, pp. 1346-1361. https://doi.org/10.1080/13803390500473720
Bieliauskas, Linas A. ; Back-Madruga, Carla ; Lindsay, Karen L. ; Snow, Kristin K. ; Kronfol, Ziad ; Lok, Anna S. ; Padmanabhan, Latha ; Fontana, Robert J. / Clinical relevance of cognitive scores in hepatitis C patients with advanced fibrosis. In: Journal of Clinical and Experimental Neuropsychology. 2006 ; Vol. 28, No. 8. pp. 1346-1361.
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