Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

Ulrike Benninghoff, Federica Cattaneo, Alessandro Aiuti, Alberto Flores-D'Arcais, Carlo Gelmetti, Matteo Viscardi, Luciano Callegaro, Massimiliano Mirolo, Alessandro Ambrosi, Maria Grazia Roncarolo, Rosa Bacchetta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.

Original languageEnglish
Pages (from-to)564-568
Number of pages5
JournalPediatric Allergy and Immunology
Volume19
Issue number6
DOIs
Publication statusPublished - Sep 2008
Externally publishedYes

Fingerprint

Job Syndrome
Interferons
Cytokines
Eczema
Therapeutics
T-Lymphocytes
Pharmaceutical Preparations
In Vitro Techniques

Keywords

  • Cytokines
  • Eczema
  • Hyper-IgE syndrome
  • Immunodeficiency
  • Interferon-α

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology

Cite this

Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome. / Benninghoff, Ulrike; Cattaneo, Federica; Aiuti, Alessandro; Flores-D'Arcais, Alberto; Gelmetti, Carlo; Viscardi, Matteo; Callegaro, Luciano; Mirolo, Massimiliano; Ambrosi, Alessandro; Roncarolo, Maria Grazia; Bacchetta, Rosa.

In: Pediatric Allergy and Immunology, Vol. 19, No. 6, 09.2008, p. 564-568.

Research output: Contribution to journalArticle

Benninghoff, U, Cattaneo, F, Aiuti, A, Flores-D'Arcais, A, Gelmetti, C, Viscardi, M, Callegaro, L, Mirolo, M, Ambrosi, A, Roncarolo, MG & Bacchetta, R 2008, 'Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome', Pediatric Allergy and Immunology, vol. 19, no. 6, pp. 564-568. https://doi.org/10.1111/j.1399-3038.2007.00683.x
Benninghoff, Ulrike ; Cattaneo, Federica ; Aiuti, Alessandro ; Flores-D'Arcais, Alberto ; Gelmetti, Carlo ; Viscardi, Matteo ; Callegaro, Luciano ; Mirolo, Massimiliano ; Ambrosi, Alessandro ; Roncarolo, Maria Grazia ; Bacchetta, Rosa. / Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome. In: Pediatric Allergy and Immunology. 2008 ; Vol. 19, No. 6. pp. 564-568.
@article{70da39e46a1f441785f5408ae53d1980,
title = "Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome",
abstract = "We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.",
keywords = "Cytokines, Eczema, Hyper-IgE syndrome, Immunodeficiency, Interferon-α",
author = "Ulrike Benninghoff and Federica Cattaneo and Alessandro Aiuti and Alberto Flores-D'Arcais and Carlo Gelmetti and Matteo Viscardi and Luciano Callegaro and Massimiliano Mirolo and Alessandro Ambrosi and Roncarolo, {Maria Grazia} and Rosa Bacchetta",
year = "2008",
month = "9",
doi = "10.1111/j.1399-3038.2007.00683.x",
language = "English",
volume = "19",
pages = "564--568",
journal = "Pediatric Allergy and Immunology",
issn = "0905-6157",
publisher = "Blackwell Munksgaard",
number = "6",

}

TY - JOUR

T1 - Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

AU - Benninghoff, Ulrike

AU - Cattaneo, Federica

AU - Aiuti, Alessandro

AU - Flores-D'Arcais, Alberto

AU - Gelmetti, Carlo

AU - Viscardi, Matteo

AU - Callegaro, Luciano

AU - Mirolo, Massimiliano

AU - Ambrosi, Alessandro

AU - Roncarolo, Maria Grazia

AU - Bacchetta, Rosa

PY - 2008/9

Y1 - 2008/9

N2 - We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.

AB - We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.

KW - Cytokines

KW - Eczema

KW - Hyper-IgE syndrome

KW - Immunodeficiency

KW - Interferon-α

UR - http://www.scopus.com/inward/record.url?scp=49749112063&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49749112063&partnerID=8YFLogxK

U2 - 10.1111/j.1399-3038.2007.00683.x

DO - 10.1111/j.1399-3038.2007.00683.x

M3 - Article

VL - 19

SP - 564

EP - 568

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

SN - 0905-6157

IS - 6

ER -