Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome

Ulrike Benninghoff, Federica Cattaneo, Alessandro Aiuti, Alberto Flores-D'Arcais, Carlo Gelmetti, Matteo Viscardi, Luciano Callegaro, Massimiliano Mirolo, Alessandro Ambrosi, Maria Grazia Roncarolo, Rosa Bacchetta

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3 Citations (Scopus)

Abstract

We are reporting on a 7-months-old boy with suspected hyper-IgE syndrome, presenting with a therapy resistant severe eczema and an overall reduction of in vitro cytokine production. Interferon-α (IFN-α) treatment resulted in a marked and stable clinical improvement and normalization of in vitro T-cell cytokine production, indicating a valid therapeutic potential of IFN-α as immunomodulating drug.

Original languageEnglish
Pages (from-to)564-568
Number of pages5
JournalPediatric Allergy and Immunology
Volume19
Issue number6
DOIs
Publication statusPublished - 1 Sep 2008

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Keywords

  • Cytokines
  • Eczema
  • Hyper-IgE syndrome
  • Immunodeficiency
  • Interferon-α

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

Cite this

Benninghoff, U., Cattaneo, F., Aiuti, A., Flores-D'Arcais, A., Gelmetti, C., Viscardi, M., Callegaro, L., Mirolo, M., Ambrosi, A., Roncarolo, M. G., & Bacchetta, R. (2008). Clinical improvement and normalized Th1 cytokine profile in early and long-term interferon-α treatment in a suspected case of hyper-IgE syndrome. Pediatric Allergy and Immunology, 19(6), 564-568. https://doi.org/10.1111/j.1399-3038.2007.00683.x