Circulating transforming growth factor-Β1 levels and the risk for kidney disease in African Americans

Manikkam Suthanthiran, Linda M. Gerber, Joseph E. Schwartz, Vijay K. Sharma, Mara Medeiros, Rosemerie Marion, Thomas G. Pickering, Phyllis August

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Abstract

Transforming growth factor-Β1 (TGF-Β1) is known to induce progression of experimental renal disease. Here we determined whether there is an association between serum levels of TGF-Β1 and the risk factors for progression of clinically relevant renal disorders in 186 black and 147 white adults, none of whom had kidney disease or diabetes. Serum TGF-Β1 protein levels were positively and significantly associated with plasma renin activity along with the systolic and diastolic blood pressure in blacks but not whites after controlling for age, gender, and body mass index. These TGF-Β1 protein levels were also significantly associated with body mass index and metabolic syndrome and more predictive of microalbuminuria in blacks than in whites. The differential association between TGF-Β1 and renal disease risk factors in blacks and whites suggests an explanation for the excess burden of end-stage renal disease in the black population, but this requires validation in an independent cohort. Whether these findings show that it is the circulating levels of TGF-Β1 that contribute to renal disease progression or the findings reflect other unmeasured factors, further longitudinal studies are needed.

Original languageEnglish
Pages (from-to)72-80
Number of pages9
JournalKidney International
Volume76
Issue number1
DOIs
Publication statusPublished - 1 Jul 2009

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Keywords

  • African Americans
  • Blood pressure
  • Hypertension kidney disease
  • PRA
  • TGF-b1

ASJC Scopus subject areas

  • Nephrology

Cite this

Suthanthiran, M., Gerber, L. M., Schwartz, J. E., Sharma, V. K., Medeiros, M., Marion, R., Pickering, T. G., & August, P. (2009). Circulating transforming growth factor-Β1 levels and the risk for kidney disease in African Americans. Kidney International, 76(1), 72-80. https://doi.org/10.1038/ki.2009.66