Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women

Silvia Barja-Fernández, Cintia Folgueira, Luisa M. Seoane, Felipe F. Casanueva, Carlos Dieguez, Cecilia Castelao, Zaida Agüera, Rosa Baños, Cristina Botella, Rafael De La Torre, Jose C. Fernández-García, Jose M. Fernández-Real, Gema Frühbeck, Javier Gpmez-Ambrosi, Susana Jiménez-Murcia, Francisco J. Tinahones, Xavier P. Estivill, Fernando Fernández-Aranda, Ruben Nogueiras

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Context: Betatrophin is produced primarily by liver and adipose tissue and has been recently reported as a novel hormone promoting β-cell proliferation and β-cell mass and improving glucose tolerance. Objective: Because it is markedly regulated by nutritional status, we hypothesized that circulating betatrophin levels might be affected by pathophysiological conditions altering body weight. Setting and Patients:Weanalyzed circulating betatrophin levels in 149 female patients, including 99 with extreme body mass index (30 anorexia nervosa, 24 obese, 45 morbid obese, and 50 healthy eating/weight controls). Outcome Measurements: Serum betatrophin levels and its correlations with different anthropometric and biochemical parameters were measured. Results: Plasma betatrophin levels were significantly elevated in anorexic patients, whereas its levels were reduced in morbidly obese women when compared with normal-weight women. Plasma betatrophin correlated negatively with weight, body mass index, fat percentage, glucose, insulin, and homeostatic model assessment index and positively correlated with high-density lipoprotein. Conclusions: These results suggest that metabolic status is an important regulator of circulating betatrophin levels.

Original languageEnglish
Pages (from-to)E1188-E1196
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number9
DOIs
Publication statusPublished - 1 Sep 2015
Externally publishedYes

Fingerprint

Anorexia
Weight control
Plasmas
Weights and Measures
Glucose
Cell proliferation
Body Mass Index
HDL Lipoproteins
Liver
Fats
Anorexia Nervosa
Hormones
Insulin
Tissue
Nutritional Status
Adipose Tissue
Body Weight
Cell Proliferation
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Barja-Fernández, S., Folgueira, C., Seoane, L. M., Casanueva, F. F., Dieguez, C., Castelao, C., ... Nogueiras, R. (2015). Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women. Journal of Clinical Endocrinology and Metabolism, 100(9), E1188-E1196. https://doi.org/10.1210/JC.2015-1595

Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women. / Barja-Fernández, Silvia; Folgueira, Cintia; Seoane, Luisa M.; Casanueva, Felipe F.; Dieguez, Carlos; Castelao, Cecilia; Agüera, Zaida; Baños, Rosa; Botella, Cristina; De La Torre, Rafael; Fernández-García, Jose C.; Fernández-Real, Jose M.; Frühbeck, Gema; Gpmez-Ambrosi, Javier; Jiménez-Murcia, Susana; Tinahones, Francisco J.; Estivill, Xavier P.; Fernández-Aranda, Fernando; Nogueiras, Ruben.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 9, 01.09.2015, p. E1188-E1196.

Research output: Contribution to journalArticle

Barja-Fernández, S, Folgueira, C, Seoane, LM, Casanueva, FF, Dieguez, C, Castelao, C, Agüera, Z, Baños, R, Botella, C, De La Torre, R, Fernández-García, JC, Fernández-Real, JM, Frühbeck, G, Gpmez-Ambrosi, J, Jiménez-Murcia, S, Tinahones, FJ, Estivill, XP, Fernández-Aranda, F & Nogueiras, R 2015, 'Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 9, pp. E1188-E1196. https://doi.org/10.1210/JC.2015-1595
Barja-Fernández S, Folgueira C, Seoane LM, Casanueva FF, Dieguez C, Castelao C et al. Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women. Journal of Clinical Endocrinology and Metabolism. 2015 Sep 1;100(9):E1188-E1196. https://doi.org/10.1210/JC.2015-1595
Barja-Fernández, Silvia ; Folgueira, Cintia ; Seoane, Luisa M. ; Casanueva, Felipe F. ; Dieguez, Carlos ; Castelao, Cecilia ; Agüera, Zaida ; Baños, Rosa ; Botella, Cristina ; De La Torre, Rafael ; Fernández-García, Jose C. ; Fernández-Real, Jose M. ; Frühbeck, Gema ; Gpmez-Ambrosi, Javier ; Jiménez-Murcia, Susana ; Tinahones, Francisco J. ; Estivill, Xavier P. ; Fernández-Aranda, Fernando ; Nogueiras, Ruben. / Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women. In: Journal of Clinical Endocrinology and Metabolism. 2015 ; Vol. 100, No. 9. pp. E1188-E1196.
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AU - Dieguez, Carlos

AU - Castelao, Cecilia

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