Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women

Silvia Barja-Fernández, Cintia Folgueira, Luisa M. Seoane, Felipe F. Casanueva, Carlos Dieguez, Cecilia Castelao, Zaida Agüera, Rosa Baños, Cristina Botella, Rafael De La Torre, Jose C. Fernández-García, Jose M. Fernández-Real, Gema Frühbeck, Javier Gpmez-Ambrosi, Susana Jiménez-Murcia, Francisco J. Tinahones, Xavier P. Estivill, Fernando Fernández-Aranda, Ruben Nogueiras

Research output: Contribution to journalArticle

30 Citations (Scopus)


Context: Betatrophin is produced primarily by liver and adipose tissue and has been recently reported as a novel hormone promoting β-cell proliferation and β-cell mass and improving glucose tolerance. Objective: Because it is markedly regulated by nutritional status, we hypothesized that circulating betatrophin levels might be affected by pathophysiological conditions altering body weight. Setting and Patients:Weanalyzed circulating betatrophin levels in 149 female patients, including 99 with extreme body mass index (30 anorexia nervosa, 24 obese, 45 morbid obese, and 50 healthy eating/weight controls). Outcome Measurements: Serum betatrophin levels and its correlations with different anthropometric and biochemical parameters were measured. Results: Plasma betatrophin levels were significantly elevated in anorexic patients, whereas its levels were reduced in morbidly obese women when compared with normal-weight women. Plasma betatrophin correlated negatively with weight, body mass index, fat percentage, glucose, insulin, and homeostatic model assessment index and positively correlated with high-density lipoprotein. Conclusions: These results suggest that metabolic status is an important regulator of circulating betatrophin levels.

Original languageEnglish
Pages (from-to)E1188-E1196
JournalJournal of Clinical Endocrinology and Metabolism
Issue number9
Publication statusPublished - 1 Sep 2015
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Barja-Fernández, S., Folgueira, C., Seoane, L. M., Casanueva, F. F., Dieguez, C., Castelao, C., Agüera, Z., Baños, R., Botella, C., De La Torre, R., Fernández-García, J. C., Fernández-Real, J. M., Frühbeck, G., Gpmez-Ambrosi, J., Jiménez-Murcia, S., Tinahones, F. J., Estivill, X. P., Fernández-Aranda, F., & Nogueiras, R. (2015). Circulating betatrophin levels are increased in anorexia and decreased in morbidly obese women. Journal of Clinical Endocrinology and Metabolism, 100(9), E1188-E1196.