Chromosomal imbalances in nasopharyngeal carcinoma

A meta-analysis of comparative genomic hybridization results

Xin Li, Ena Wang, Ying Dong Zhao, Jia Qiang Ren, Ping Jin, Kai Tai Yao, Francesco M. Marincola

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Nasopharyngeal carcinoma (NPC) is a highly prevalent disease in Southeast Asia and its prevalence is clearly affected by genetic background. Various theories have been suggested for its high incidence in this geographical region but to these days no conclusive explanation has been identified. Chromosomal imbalances identifiable through comparative genomic hybridization may shed some light on common genetic alterations that may be of relevance to the onset and progression of NPC. Review of the literature, however, reveals contradictory results among reported findings possibly related to factors associated with patient selection, stage of disease, differences in methodological details etc. To increase the power of the analysis and attempt to identify commonalities among the reported findings, we performed a meta-analysis of results described in NPC tissues based on chromosomal comparative genomic hybridization (CGH). This meta-analysis revealed consistent patters in chromosomal abnormalities that appeared to cluster in specific "hot spots" along the genome following a stage-dependent progression.

Original languageEnglish
Article number4
JournalJournal of Translational Medicine
Volume4
DOIs
Publication statusPublished - 19 Jan 2006
Externally publishedYes

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Comparative Genomic Hybridization
Meta-Analysis
Geographical regions
Southeastern Asia
Genes
Tissue
Chromosome Aberrations
Patient Selection
Genome
Incidence
Nasopharyngeal carcinoma

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chromosomal imbalances in nasopharyngeal carcinoma : A meta-analysis of comparative genomic hybridization results. / Li, Xin; Wang, Ena; Zhao, Ying Dong; Ren, Jia Qiang; Jin, Ping; Yao, Kai Tai; Marincola, Francesco M.

In: Journal of Translational Medicine, Vol. 4, 4, 19.01.2006.

Research output: Contribution to journalReview article

Li, Xin ; Wang, Ena ; Zhao, Ying Dong ; Ren, Jia Qiang ; Jin, Ping ; Yao, Kai Tai ; Marincola, Francesco M. / Chromosomal imbalances in nasopharyngeal carcinoma : A meta-analysis of comparative genomic hybridization results. In: Journal of Translational Medicine. 2006 ; Vol. 4.
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