Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D

a cross-sectional analysis in population-based data

Susanne Vogt, Simone Wahl, Johannes Kettunen, Susanne Breitner, Gabi Kastenmüller, Christian Gieger, Karsten Suhre, Melanie Waldenberger, Jürgen Kratzsch, Markus Perola, Veikko Salomaa, Stefan Blankenberg, Tanja Zeller, Pasi Soininen, Antti J. Kangas, Annette Peters, Harald Grallert, Mika Ala-Korpela, Barbara Thorand

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

BACKGROUND: Numerous observational studies have observed associations between vitamin D deficiency and cardiometabolic diseases, but these findings might be confounded by obesity. A characterization of the metabolic profile associated with serum 25-hydroxyvitamin D [25(OH)D] levels, in general and stratified by abdominal obesity, may help to untangle the relationship between vitamin D, obesity and cardiometabolic health.

METHODS: Serum metabolomics measurements were obtained from a nuclear magnetic resonance spectroscopy (NMR)- and a mass spectrometry (MS)-based platform. The discovery was conducted in 1726 participants of the population-based KORA-F4 study, in which the associations of the concentrations of 415 metabolites with 25(OH)D levels were assessed in linear models. The results were replicated in 6759 participants (NMR) and 609 (MS) participants, respectively, of the population-based FINRISK 1997 study.

RESULTS: Mean [standard deviation (SD)] 25(OH)D levels were 15.2 (7.5) ng/ml in KORA F4 and 13.8 (5.9) ng/ml in FINRISK 1997; 37 metabolites were associated with 25(OH)D in KORA F4 at P < 0.05/415. Of these, 30 associations were replicated in FINRISK 1997 at P < 0.05/37. Among these were constituents of (very) large very-low-density lipoprotein and small low-density lipoprotein subclasses and related measures like serum triglycerides as well as fatty acids and measures reflecting the degree of fatty acid saturation. The observed associations were independent of waist circumference and generally similar in abdominally obese and non-obese participants.

CONCLUSIONS: Independently of abdominal obesity, higher 25(OH)D levels were associated with a metabolite profile characterized by lower concentrations of atherogenic lipids and a higher degree of fatty acid polyunsaturation. These results indicate that the relationship between vitamin D deficiency and cardiometabolic diseases is unlikely to merely reflect obesity-related pathomechanisms.

Original languageEnglish
Pages (from-to)1469-1481
Number of pages13
JournalInternational Journal of Epidemiology
Volume45
Issue number5
Publication statusPublished - 1 Oct 2016

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Metabolome
Obesity
Cross-Sectional Studies
Serum
Population
Deficiency Diseases
Vitamin D Deficiency
Fatty Acids
Abdominal Obesity
Mass Spectrometry
Magnetic Resonance Spectroscopy
Metabolomics
VLDL Lipoproteins
Waist Circumference
25-hydroxyvitamin D
LDL Lipoproteins
Vitamin D
Observational Studies
Linear Models
Triglycerides

Keywords

  • 25(OH)D
  • metabolomics
  • molecular epidemiology
  • obesity
  • vitamin D

ASJC Scopus subject areas

  • Epidemiology

Cite this

Vogt, S., Wahl, S., Kettunen, J., Breitner, S., Kastenmüller, G., Gieger, C., ... Thorand, B. (2016). Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data. International Journal of Epidemiology, 45(5), 1469-1481.

Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D : a cross-sectional analysis in population-based data. / Vogt, Susanne; Wahl, Simone; Kettunen, Johannes; Breitner, Susanne; Kastenmüller, Gabi; Gieger, Christian; Suhre, Karsten; Waldenberger, Melanie; Kratzsch, Jürgen; Perola, Markus; Salomaa, Veikko; Blankenberg, Stefan; Zeller, Tanja; Soininen, Pasi; Kangas, Antti J.; Peters, Annette; Grallert, Harald; Ala-Korpela, Mika; Thorand, Barbara.

In: International Journal of Epidemiology, Vol. 45, No. 5, 01.10.2016, p. 1469-1481.

Research output: Contribution to journalArticle

Vogt, S, Wahl, S, Kettunen, J, Breitner, S, Kastenmüller, G, Gieger, C, Suhre, K, Waldenberger, M, Kratzsch, J, Perola, M, Salomaa, V, Blankenberg, S, Zeller, T, Soininen, P, Kangas, AJ, Peters, A, Grallert, H, Ala-Korpela, M & Thorand, B 2016, 'Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D: a cross-sectional analysis in population-based data', International Journal of Epidemiology, vol. 45, no. 5, pp. 1469-1481.
Vogt, Susanne ; Wahl, Simone ; Kettunen, Johannes ; Breitner, Susanne ; Kastenmüller, Gabi ; Gieger, Christian ; Suhre, Karsten ; Waldenberger, Melanie ; Kratzsch, Jürgen ; Perola, Markus ; Salomaa, Veikko ; Blankenberg, Stefan ; Zeller, Tanja ; Soininen, Pasi ; Kangas, Antti J. ; Peters, Annette ; Grallert, Harald ; Ala-Korpela, Mika ; Thorand, Barbara. / Characterization of the metabolic profile associated with serum 25-hydroxyvitamin D : a cross-sectional analysis in population-based data. In: International Journal of Epidemiology. 2016 ; Vol. 45, No. 5. pp. 1469-1481.
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AU - Breitner, Susanne

AU - Kastenmüller, Gabi

AU - Gieger, Christian

AU - Suhre, Karsten

AU - Waldenberger, Melanie

AU - Kratzsch, Jürgen

AU - Perola, Markus

AU - Salomaa, Veikko

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Soininen, Pasi

AU - Kangas, Antti J.

AU - Peters, Annette

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N2 - BACKGROUND: Numerous observational studies have observed associations between vitamin D deficiency and cardiometabolic diseases, but these findings might be confounded by obesity. A characterization of the metabolic profile associated with serum 25-hydroxyvitamin D [25(OH)D] levels, in general and stratified by abdominal obesity, may help to untangle the relationship between vitamin D, obesity and cardiometabolic health.METHODS: Serum metabolomics measurements were obtained from a nuclear magnetic resonance spectroscopy (NMR)- and a mass spectrometry (MS)-based platform. The discovery was conducted in 1726 participants of the population-based KORA-F4 study, in which the associations of the concentrations of 415 metabolites with 25(OH)D levels were assessed in linear models. The results were replicated in 6759 participants (NMR) and 609 (MS) participants, respectively, of the population-based FINRISK 1997 study.RESULTS: Mean [standard deviation (SD)] 25(OH)D levels were 15.2 (7.5) ng/ml in KORA F4 and 13.8 (5.9) ng/ml in FINRISK 1997; 37 metabolites were associated with 25(OH)D in KORA F4 at P < 0.05/415. Of these, 30 associations were replicated in FINRISK 1997 at P < 0.05/37. Among these were constituents of (very) large very-low-density lipoprotein and small low-density lipoprotein subclasses and related measures like serum triglycerides as well as fatty acids and measures reflecting the degree of fatty acid saturation. The observed associations were independent of waist circumference and generally similar in abdominally obese and non-obese participants.CONCLUSIONS: Independently of abdominal obesity, higher 25(OH)D levels were associated with a metabolite profile characterized by lower concentrations of atherogenic lipids and a higher degree of fatty acid polyunsaturation. These results indicate that the relationship between vitamin D deficiency and cardiometabolic diseases is unlikely to merely reflect obesity-related pathomechanisms.

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