Characterization of a novel bioactive composite using advanced X-ray computed tomography

Gautam Gupta, Ali Zbib, Ahmed El-Ghannam, Marwan Khraisheh, Hussein Zbib

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A novel bioactive, porous silica-calcium phosphate nanocomposite (SCPC) that can be used to treat large bone defects in load-bearing positions has been tested and has shown great potential for applications in tissue engineering. Porosity is essential to the performance of the composite material as a tissue engineering scaffold, as porous scaffolds provide a physical, 3-D template to support new tissue formation. However, porosity characterization using conventional techniques such as porosimetry or scanning electron microscopy requires extensive preparation of samples and may destroy important features during preparation and analysis stage. In this work, the new composite is characterized using an advanced high resolution X-ray computed tomography, which is a non-destructive testing technique that allows construction of the 3-D topology of the microstructure. The results clearly show the effectiveness and versatility of this technique in characterizing the porous architecture of the novel composite biomaterial. The pore distribution, morphology and interconnectivity in the composite scaffolds were found to be ideal for use in tissue engineering applications.

Original languageEnglish
Pages (from-to)423-428
Number of pages6
JournalComposite Structures
Volume71
Issue number3-4
DOIs
Publication statusPublished - 1 Dec 2005
Externally publishedYes

Fingerprint

Tomography
Tissue engineering
X rays
Composite materials
Scaffolds (biology)
Bearings (structural)
Porosity
Tissue Scaffolds
Bioelectric potentials
Calcium phosphate
Biocompatible Materials
Nondestructive examination
Biomaterials
Scaffolds
Nanocomposites
Bone
Silica
Topology
Tissue
Defects

Keywords

  • Bioceramics
  • Bone-graft
  • Porosity
  • X-ray computed tomography

ASJC Scopus subject areas

  • Civil and Structural Engineering
  • Ceramics and Composites

Cite this

Characterization of a novel bioactive composite using advanced X-ray computed tomography. / Gupta, Gautam; Zbib, Ali; El-Ghannam, Ahmed; Khraisheh, Marwan; Zbib, Hussein.

In: Composite Structures, Vol. 71, No. 3-4, 01.12.2005, p. 423-428.

Research output: Contribution to journalArticle

Gupta, Gautam ; Zbib, Ali ; El-Ghannam, Ahmed ; Khraisheh, Marwan ; Zbib, Hussein. / Characterization of a novel bioactive composite using advanced X-ray computed tomography. In: Composite Structures. 2005 ; Vol. 71, No. 3-4. pp. 423-428.
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