Characterisation of three microsatellite polymorphisms (D21S1262, D21S1419 and D21S1421) from band 21q22.1

Assumpció Bosch, Jordi Guimerà, David Patterson, Xavier Estivill

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We have isolated three clones, containing highly polymorphic CA-repeat sequences, from a human chromosome 21 phage library (LA21NS01). These clones have been localised to band q22.1 by using a chromosome 21 somatic cell hybrid panel. D21S1262 is located between breakpoints 6918-8a1 and 32S, and D21S1419 and D21S1421 are localised between breakpoints JC6-A and MRC2G. Their observed heterozygosities range between 0.75 and 0.85 as shown by unrelated reference parents from the Centre d'Etude du Polymorphisme Humain. These highly polymorphic markers should be useful for improving the analysis of this region of chromosome 21, which contains important genes such as SOD1, GART and IFNAR.

Original languageEnglish
Pages (from-to)596-598
Number of pages3
JournalHuman Genetics
Issue number5
Publication statusPublished - 1 May 1995


ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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