Cerebrovascular damage in late-life depression is associated with structural and functional abnormalities of subcutaneous small arteries

Adam S. Greenstein, Raghupathy Paranthaman, Alistair Burns, Alan Jackson, Rayaz Malik, Robert C. Baldwin, Anthony M. Heagerty

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Late-life depression is increasingly viewed as a vascular illness because of patients exhibiting characteristic white matter brain lesions and in vivo large artery endothelial dysfunction. However, the "vascular depression" hypothesis pertains to the microvasculature, and this circulation has not been studied in this context. Our objective was to examine structure and function of small subcutaneous arteries in patients with late-life depression. Thus, 16 patients aged 71.8±4.0 years with late-life depression were compared with 15 control participants aged 72.1±5.9 years. There were similar cardiovascular profiles between the 2 groups. All of the participants underwent MRI brain scans and subcutaneous gluteal fat biopsy from which small arteries were isolated and studied using pressure myography. Cerebral microvascular damage in depressed patients was confirmed by assessment of basal ganglia Virchow-Robin space scores (depressed patients 3.9±1.7 versus controls: 2.5±1.6; P=0.01). Contractility to norepinephrine was equivalent in both groups, but relaxation of the small arteries to acetylcholine was significantly reduced in depressed patients (84.0±4.0%) compared with control participants (96.0±1.4%; P=0.012). This difference in arterial relaxation was reduced but not entirely eliminated when NO synthase was inhibited. Depressed patients also exhibited hypertrophic wall growth with an increase in medial cross-sectional area (P=0.035, multiple ANOVA and wall thickness; P=0.04, multiple ANOVA). In conclusion, despite similar cardiovascular profiles, depressed patients with cerebral microvascular damage show abnormalities of subcutaneous small artery structure and function.

Original languageEnglish
Pages (from-to)734-740
Number of pages7
JournalHypertension
Volume56
Issue number4
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

Fingerprint

Arteries
Blood Vessels
Analysis of Variance
Myography
Songbirds
Subcutaneous Fat
Brain
Microvessels
Basal Ganglia
Nitric Oxide Synthase
Acetylcholine
Norepinephrine
Magnetic Resonance Imaging
Biopsy
Pressure
Growth

Keywords

  • ageing
  • cerebrovascular disorders
  • endothelium
  • remodeling
  • small artery

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Cerebrovascular damage in late-life depression is associated with structural and functional abnormalities of subcutaneous small arteries. / Greenstein, Adam S.; Paranthaman, Raghupathy; Burns, Alistair; Jackson, Alan; Malik, Rayaz; Baldwin, Robert C.; Heagerty, Anthony M.

In: Hypertension, Vol. 56, No. 4, 10.2010, p. 734-740.

Research output: Contribution to journalArticle

Greenstein, Adam S. ; Paranthaman, Raghupathy ; Burns, Alistair ; Jackson, Alan ; Malik, Rayaz ; Baldwin, Robert C. ; Heagerty, Anthony M. / Cerebrovascular damage in late-life depression is associated with structural and functional abnormalities of subcutaneous small arteries. In: Hypertension. 2010 ; Vol. 56, No. 4. pp. 734-740.
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