Cerebral evoked potentials - A method of quantification of central nervous system response to esophageal pain

Kenneth R. DeVault, Sabrina Beacham, Leopold Streletz, Donald O. Castell

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Cerebral evoked potentials (EPs) represent a new technique for the evaluation of afferent outflow from the gastrointestinal tract. We compared EPs obtained with distension of the distal and proximal esophagus. Responses were recorded with the balloon 5 cm proximal to the lower esophageal sphincter and 3 cm distal to the upper esophageal sphincter. Balloon stimulation resulted in cortical responses recorded by midline scalp electrodes (CZ′, PZ, and OZ by the International 10-20 system) in normal volunteers. EP responses consisted of two negative (N1, N2) and one positive (P1) deflections. The proximal esophageal latency of N1 was shorter in all three leads. The latency to P1 was shorter with proximal stimulation in lead CZ′ only, and N2 latencies were not different. Amplitudes expressed as the difference between N1 and P1, and P1 and N2 were not different. When two sets of potentials several minutes apart from the proximal position were compared, a decrease in amplitude with the second set of stimulations was noted. Esophageal EP recording is a new technique that may provide information about the integrity and function of the sensory innervation of the esophagus.

Original languageEnglish
Pages (from-to)2241-2246
Number of pages6
JournalDigestive Diseases and Sciences
Volume38
Issue number12
DOIs
Publication statusPublished - Dec 1993
Externally publishedYes

Fingerprint

Evoked Potentials
Central Nervous System
Pain
Esophagus
Upper Esophageal Sphincter
Lower Esophageal Sphincter
Scalp
Gastrointestinal Tract
Healthy Volunteers
Electrodes

Keywords

  • cerebral evoked potentials
  • esophagus
  • mechanical stimulation
  • nociceptors

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cerebral evoked potentials - A method of quantification of central nervous system response to esophageal pain. / DeVault, Kenneth R.; Beacham, Sabrina; Streletz, Leopold; Castell, Donald O.

In: Digestive Diseases and Sciences, Vol. 38, No. 12, 12.1993, p. 2241-2246.

Research output: Contribution to journalArticle

DeVault, Kenneth R. ; Beacham, Sabrina ; Streletz, Leopold ; Castell, Donald O. / Cerebral evoked potentials - A method of quantification of central nervous system response to esophageal pain. In: Digestive Diseases and Sciences. 1993 ; Vol. 38, No. 12. pp. 2241-2246.
@article{daddbd6e4b7d4db9a14aea5b4d671f7f,
title = "Cerebral evoked potentials - A method of quantification of central nervous system response to esophageal pain",
abstract = "Cerebral evoked potentials (EPs) represent a new technique for the evaluation of afferent outflow from the gastrointestinal tract. We compared EPs obtained with distension of the distal and proximal esophagus. Responses were recorded with the balloon 5 cm proximal to the lower esophageal sphincter and 3 cm distal to the upper esophageal sphincter. Balloon stimulation resulted in cortical responses recorded by midline scalp electrodes (CZ′, PZ, and OZ by the International 10-20 system) in normal volunteers. EP responses consisted of two negative (N1, N2) and one positive (P1) deflections. The proximal esophageal latency of N1 was shorter in all three leads. The latency to P1 was shorter with proximal stimulation in lead CZ′ only, and N2 latencies were not different. Amplitudes expressed as the difference between N1 and P1, and P1 and N2 were not different. When two sets of potentials several minutes apart from the proximal position were compared, a decrease in amplitude with the second set of stimulations was noted. Esophageal EP recording is a new technique that may provide information about the integrity and function of the sensory innervation of the esophagus.",
keywords = "cerebral evoked potentials, esophagus, mechanical stimulation, nociceptors",
author = "DeVault, {Kenneth R.} and Sabrina Beacham and Leopold Streletz and Castell, {Donald O.}",
year = "1993",
month = "12",
doi = "10.1007/BF01299903",
language = "English",
volume = "38",
pages = "2241--2246",
journal = "American Journal of Digestive Diseases",
issn = "0002-9211",
publisher = "Springer New York",
number = "12",

}

TY - JOUR

T1 - Cerebral evoked potentials - A method of quantification of central nervous system response to esophageal pain

AU - DeVault, Kenneth R.

AU - Beacham, Sabrina

AU - Streletz, Leopold

AU - Castell, Donald O.

PY - 1993/12

Y1 - 1993/12

N2 - Cerebral evoked potentials (EPs) represent a new technique for the evaluation of afferent outflow from the gastrointestinal tract. We compared EPs obtained with distension of the distal and proximal esophagus. Responses were recorded with the balloon 5 cm proximal to the lower esophageal sphincter and 3 cm distal to the upper esophageal sphincter. Balloon stimulation resulted in cortical responses recorded by midline scalp electrodes (CZ′, PZ, and OZ by the International 10-20 system) in normal volunteers. EP responses consisted of two negative (N1, N2) and one positive (P1) deflections. The proximal esophageal latency of N1 was shorter in all three leads. The latency to P1 was shorter with proximal stimulation in lead CZ′ only, and N2 latencies were not different. Amplitudes expressed as the difference between N1 and P1, and P1 and N2 were not different. When two sets of potentials several minutes apart from the proximal position were compared, a decrease in amplitude with the second set of stimulations was noted. Esophageal EP recording is a new technique that may provide information about the integrity and function of the sensory innervation of the esophagus.

AB - Cerebral evoked potentials (EPs) represent a new technique for the evaluation of afferent outflow from the gastrointestinal tract. We compared EPs obtained with distension of the distal and proximal esophagus. Responses were recorded with the balloon 5 cm proximal to the lower esophageal sphincter and 3 cm distal to the upper esophageal sphincter. Balloon stimulation resulted in cortical responses recorded by midline scalp electrodes (CZ′, PZ, and OZ by the International 10-20 system) in normal volunteers. EP responses consisted of two negative (N1, N2) and one positive (P1) deflections. The proximal esophageal latency of N1 was shorter in all three leads. The latency to P1 was shorter with proximal stimulation in lead CZ′ only, and N2 latencies were not different. Amplitudes expressed as the difference between N1 and P1, and P1 and N2 were not different. When two sets of potentials several minutes apart from the proximal position were compared, a decrease in amplitude with the second set of stimulations was noted. Esophageal EP recording is a new technique that may provide information about the integrity and function of the sensory innervation of the esophagus.

KW - cerebral evoked potentials

KW - esophagus

KW - mechanical stimulation

KW - nociceptors

UR - http://www.scopus.com/inward/record.url?scp=0027716659&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027716659&partnerID=8YFLogxK

U2 - 10.1007/BF01299903

DO - 10.1007/BF01299903

M3 - Article

VL - 38

SP - 2241

EP - 2246

JO - American Journal of Digestive Diseases

JF - American Journal of Digestive Diseases

SN - 0002-9211

IS - 12

ER -