Cell death versus cell survival instructed by supramolecular cohesion of nanostructures

Christina J. Newcomb, Shantanu Sur, Julia H. Ortony, One-Sun Lee, John B. Matson, Job Boekhoven, Jeong Min Yu, George C. Schatz, Samuel I. Stupp

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Many naturally occurring peptides containing cationic and hydrophobic domains have evolved to interact with mammalian cell membranes and have been incorporated into materials for non-viral gene delivery, cancer therapy or treatment of microbial infections. Their electrostatic attraction to the negatively charged cell surface and hydrophobic interactions with the membrane lipids enable intracellular delivery or cell lysis. Although the effects of hydrophobicity and cationic charge of soluble molecules on the cell membrane are well known, the interactions between materials with these molecular features and cells remain poorly understood. Here we report that varying the cohesive forces within nanofibres of supramolecular materials with nearly identical cationic and hydrophobic structure instruct cell death or cell survival. Weak intermolecular bonds promote cell death through disruption of lipid membranes, while materials reinforced by hydrogen bonds support cell viability. These findings provide new strategies to design biomaterials that interact with the cell membrane.

Original languageEnglish
Article number3321
JournalNature Communications
Volume5
DOIs
Publication statusPublished - 17 Feb 2014
Externally publishedYes

Fingerprint

Nanostructures
cohesion
Cell death
death
Cell Survival
Cell Death
Cell membranes
Cells
Cell Membrane
Membrane Lipids
Hydrophobic and Hydrophilic Interactions
Nanofibers
lipids
delivery
Neoplasm Genes
cells
Biocompatible Materials
membranes
Static Electricity
Cell Communication

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Newcomb, C. J., Sur, S., Ortony, J. H., Lee, O-S., Matson, J. B., Boekhoven, J., ... Stupp, S. I. (2014). Cell death versus cell survival instructed by supramolecular cohesion of nanostructures. Nature Communications, 5, [3321]. https://doi.org/10.1038/ncomms4321

Cell death versus cell survival instructed by supramolecular cohesion of nanostructures. / Newcomb, Christina J.; Sur, Shantanu; Ortony, Julia H.; Lee, One-Sun; Matson, John B.; Boekhoven, Job; Yu, Jeong Min; Schatz, George C.; Stupp, Samuel I.

In: Nature Communications, Vol. 5, 3321, 17.02.2014.

Research output: Contribution to journalArticle

Newcomb, CJ, Sur, S, Ortony, JH, Lee, O-S, Matson, JB, Boekhoven, J, Yu, JM, Schatz, GC & Stupp, SI 2014, 'Cell death versus cell survival instructed by supramolecular cohesion of nanostructures', Nature Communications, vol. 5, 3321. https://doi.org/10.1038/ncomms4321
Newcomb, Christina J. ; Sur, Shantanu ; Ortony, Julia H. ; Lee, One-Sun ; Matson, John B. ; Boekhoven, Job ; Yu, Jeong Min ; Schatz, George C. ; Stupp, Samuel I. / Cell death versus cell survival instructed by supramolecular cohesion of nanostructures. In: Nature Communications. 2014 ; Vol. 5.
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