CD4+ T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions

A. W. Sylwester, J. C. Grivel, W. Fitzgerald, J. L. Rossio, J. D. Lifson, L. B. Margolis

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Abstract

We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4+ T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4+ T-cell depletion, consistent with mechanisms requiring productive infection.

Original languageEnglish
Pages (from-to)9345-9347
Number of pages3
JournalJournal of Virology
Volume72
Issue number11
Publication statusPublished - 1 Nov 1998

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ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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