CD4+ T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions

A. W. Sylwester, Jean-Charles B. Grivel, W. Fitzgerald, J. L. Rossio, J. D. Lifson, L. B. Margolis

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We tested infectious human immunodeficiency virus type 1 (HIV-1), noninfectious but conformationally authentic inactivated whole HIV-1 virions, and purified gp120 for the ability to induce depletion of CD4+ T cells in human lymphoid tissues ex vivo. Infectious CXCR4-tropic HIV-1, but not matched inactivated virions or gp120, mediated CD4+ T-cell depletion, consistent with mechanisms requiring productive infection.

Original languageEnglish
Pages (from-to)9345-9347
Number of pages3
JournalJournal of Virology
Volume72
Issue number11
Publication statusPublished - Nov 1998
Externally publishedYes

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Lymphocyte Depletion
Lymphoid Tissue
Virion
HIV-1
T-Lymphocytes
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

CD4+ T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions. / Sylwester, A. W.; Grivel, Jean-Charles B.; Fitzgerald, W.; Rossio, J. L.; Lifson, J. D.; Margolis, L. B.

In: Journal of Virology, Vol. 72, No. 11, 11.1998, p. 9345-9347.

Research output: Contribution to journalArticle

Sylwester, A. W. ; Grivel, Jean-Charles B. ; Fitzgerald, W. ; Rossio, J. L. ; Lifson, J. D. ; Margolis, L. B. / CD4+ T-lymphocyte depletion in human lymphoid tissue ex vivo is not induced by noninfectious human immunodeficiency virus type 1 virions. In: Journal of Virology. 1998 ; Vol. 72, No. 11. pp. 9345-9347.
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