Ca2+ signaling, genes and the cell cycle

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33 Citations (Scopus)

Abstract

Changes in the concentration and spatial distribution of Ca2+ ions in the cytoplasm constitute a ubiquitous intracellular signaling module in cellular physiology. With the advent of Ca2+ dyes that allow direct visualization of Ca2+ transients, combined with powerful experimental tools such as electrophysiological recordings, intracellular Ca2+ transients have been implicated in practically every aspect of cellular physiology, including cellular proliferation. Ca2+ signals are associated with different phases of the cell cycle and interfering with Ca2+ signaling or downstream pathways often disrupts progression of the cell cycle. Although there exists a dependence between Ca2+ signals and the cell cycle the mechanisms involved are not well defined and given the cross-talk between Ca2+ and other signaling modules, it is difficult to assess the exact role of Ca2+ signals in cell cycle progression. Two exceptions however, include fertilization and T-cell activation, where well-defined roles for Ca2+ signals in mediating progression through specific stages of the cell cycle have been clearly established. In the case of T-cell activation Ca2+ regulates entry into the cell cycle through the induction of gene transcription.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalCell Calcium
Volume49
Issue number5
DOIs
Publication statusPublished - 2011

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Keywords

  • Ca signaling
  • Cell cycle
  • Fertilization
  • Gene expression
  • T-cell activation

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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