Ca2+ signaling differentiation during oocyte maturation

Research output: Contribution to journalShort survey

58 Citations (Scopus)

Abstract

Oocyte maturation is an essential cellular differentiation pathway that prepares the egg for activation at fertilization leading to the initiation of embryogenesis. An integral attribute of oocyte maturation is the remodeling of Ca2+ signaling pathways endowing the egg with the capacity to produce a specialized Ca2+ transient at fertilization that is necessary and sufficient for egg activation. Consequently, mechanistic elucidation of Ca 2+ signaling differentiation during oocyte maturation is fundamental to our understanding of egg activation, and offers a glimpse into Ca 2+ signaling regulation during the cell cycle.

Original languageEnglish
Pages (from-to)331-340
Number of pages10
JournalJournal of Cellular Physiology
Volume213
Issue number2
DOIs
Publication statusPublished - Nov 2007
Externally publishedYes

Fingerprint

Oocytes
Ovum
Chemical activation
Fertilization
Cells
Embryonic Development
Cell Cycle

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Ca2+ signaling differentiation during oocyte maturation. / Machaca, Khaled.

In: Journal of Cellular Physiology, Vol. 213, No. 2, 11.2007, p. 331-340.

Research output: Contribution to journalShort survey

@article{41664b174e8443a7951fcb5a148b0d7e,
title = "Ca2+ signaling differentiation during oocyte maturation",
abstract = "Oocyte maturation is an essential cellular differentiation pathway that prepares the egg for activation at fertilization leading to the initiation of embryogenesis. An integral attribute of oocyte maturation is the remodeling of Ca2+ signaling pathways endowing the egg with the capacity to produce a specialized Ca2+ transient at fertilization that is necessary and sufficient for egg activation. Consequently, mechanistic elucidation of Ca 2+ signaling differentiation during oocyte maturation is fundamental to our understanding of egg activation, and offers a glimpse into Ca 2+ signaling regulation during the cell cycle.",
author = "Khaled Machaca",
year = "2007",
month = "11",
doi = "10.1002/jcp.21194",
language = "English",
volume = "213",
pages = "331--340",
journal = "Journal of Cellular Physiology",
issn = "0021-9541",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Ca2+ signaling differentiation during oocyte maturation

AU - Machaca, Khaled

PY - 2007/11

Y1 - 2007/11

N2 - Oocyte maturation is an essential cellular differentiation pathway that prepares the egg for activation at fertilization leading to the initiation of embryogenesis. An integral attribute of oocyte maturation is the remodeling of Ca2+ signaling pathways endowing the egg with the capacity to produce a specialized Ca2+ transient at fertilization that is necessary and sufficient for egg activation. Consequently, mechanistic elucidation of Ca 2+ signaling differentiation during oocyte maturation is fundamental to our understanding of egg activation, and offers a glimpse into Ca 2+ signaling regulation during the cell cycle.

AB - Oocyte maturation is an essential cellular differentiation pathway that prepares the egg for activation at fertilization leading to the initiation of embryogenesis. An integral attribute of oocyte maturation is the remodeling of Ca2+ signaling pathways endowing the egg with the capacity to produce a specialized Ca2+ transient at fertilization that is necessary and sufficient for egg activation. Consequently, mechanistic elucidation of Ca 2+ signaling differentiation during oocyte maturation is fundamental to our understanding of egg activation, and offers a glimpse into Ca 2+ signaling regulation during the cell cycle.

UR - http://www.scopus.com/inward/record.url?scp=34848895752&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34848895752&partnerID=8YFLogxK

U2 - 10.1002/jcp.21194

DO - 10.1002/jcp.21194

M3 - Short survey

C2 - 17620315

AN - SCOPUS:34848895752

VL - 213

SP - 331

EP - 340

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

SN - 0021-9541

IS - 2

ER -