Cardiovascular pharmacology of CPU-23: A novel calcium channel blocker

Hui Dong, Gareth J. Waldron, William C. Cole, Christopher Triggle

Research output: Contribution to journalArticle

Abstract

The results of our studies conducted at the molecular, cellular, tissue, organ, and whole animals levels suggest that CPU-23 is a novel calcium channel blocker. This is further confirmed by recent studies utilizing the path-clamp technique, in which CPU-23 (1-10 μM) dose-dependently blocked inward Ca2+ currents via L-type Ca2+ channels in single smooth muscle cells isolated from the rat tail artery. Although derived from tetrandrine, CPU-23 interacts at distinct binding sites on L-type calcium channels and exerts a more potent biological action than tetrandrine. These data suggest that CPU-23, because of its novel and unique chemical structure, may be a useful tool for the study of L-type calcium channels. The obvious antihypertensive and antiarrhythmic actions of CPU-23 and its respiratory effects indicate that CPU-23 may be a useful therapeutic agent worthy of further study and development. One weakness of CPU-23 is that its potency and selectivity for the vasculature is less than those of dihydropyridine derivatives, but this may be improved by a better understanding of the structure-activity relationship of tetrahydroisoquinolines and their interaction at L-type calcium channels. This could be accomplished, for instance, by further studies of the effects of substituted tetrahydroisoquinolines on [3H]nitrendipine binding.

Original languageEnglish
Pages (from-to)364-379
Number of pages16
JournalCardiovascular Drug Reviews
Volume14
Issue number4
Publication statusPublished - 1996
Externally publishedYes

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Keywords

  • Antiarrhythmic
  • Antihypertensive
  • Calcium channel blocker
  • Cardiac depression
  • CPU-23
  • Vasodilatation

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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