Cardiovascular Disorders and Epigenetics

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cardiovascular disease is the leading cause of death worldwide. With the continuous increase in the prevalence and incidence of cardiovascular disorders, it has become imperative to understand more in depth their pathophysiology and search for novel biomarkers and therapies. Epigenetics refers to the heritable changes in gene expression that are not caused by the DNA sequence itself. Mounting evidence suggests that cardiovascular risk factors such as hypertension, diabetes, obesity, and smoking are associated with changes of epigenetic components. Additionally, these risk factors may trigger modifications within the epigenome, affecting the expression of several genes and inducing cardiac pathologies such as atherosclerotic disease, heart failure, and hypertrophic cardiomyopathy. Emerging experimental data are showing that epigenetic-modifying agents can reverse some pathological cardiovascular conditions. However, it is still unknown whether these approaches will be successfully translated into cardiovascular drugs.

Original languageEnglish
Title of host publicationMedical Epigenetics
PublisherElsevier Inc.
Pages243-256
Number of pages14
ISBN (Electronic)9780128032404
ISBN (Print)9780128032398
DOIs
Publication statusPublished - 1 Jul 2016
Externally publishedYes

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Keywords

  • Atherosclerosis
  • Cardiology
  • Cardiovascular disease
  • Coronary artery disease
  • DNA methylation
  • Epigenetics
  • Heart failure
  • Hypertrophic cardiomyopathy
  • Ischemic heart disease
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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