Cardiac angiogenesis and gene therapy: A strategy for myocardial revascularization

Adam H. Hamawy, Leonard Y. Lee, Ronald G. Crystal, Todd K. Rosengart

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Angiogenesis, the de novo formation of new vasculature, is a critical response to ischemia that provides neovascularization of ischemic tissues. In therapeutic angiogenesis, an angiogen-a mediator that induces angiogenesis-is delivered to targeted tissues, augmenting the native angiogenic process and enhancing reperfusion of ischemic tissues. Gene transfer is a novel means of providing therapeutic angiogenesis: the cDNA coding for specific angiogens, rather than the proteins themselves, is administered to the tissues in which angiogenesis is desired. This review is focused on therapeutic angiogenesis based on gene transfer strategies for the provision of myocardial revascularization. Cun-Opin Cardiol 1999, 14:515-522.

Original languageEnglish
Pages (from-to)515-522
Number of pages8
JournalCurrent Opinion in Cardiology
Volume14
Issue number6
DOIs
Publication statusPublished - 1 Dec 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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