Cardiac and Carotid Markers Link with Accelerated Brain Atrophy

The AGES-Reykjavik Study (Age, Gene/Environment Susceptibility-Reykjavik)

Behnam Sabayan, Mark A. Van Buchem, Sigurdur Sigurdsson, Qian Zhang, Osorio Meirelles, Tamara B. Harris, Vilmundur Gudnason, Andrew E. Arai, Lenore J. Launer

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objective - Pathologies in the heart-brain axis might, independently or in combination, accelerate the process of brain parenchymal loss. We aimed to investigate the association of serum N-terminal brain natriuretic peptide (NT-proBNP), as a marker of cardiac dysfunction, and carotid intima media thickness (CIMT), as a marker of carotid atherosclerosis burden, with structural brain changes. Approach and Results - In the longitudinal population-based AGES-Reykjavik study (Age, Gene/Environment Susceptibility-Reykjavik), we included 2430 subjects (mean age, 74.6 years; 41.4% men) with baseline data on NT-proBNP and CITM (assessed by ultrasound imaging). Participants underwent a high-resolution brain magnetic resonance imaging at baseline and 5 years later to assess total brain (TBV), gray matter, and white matter volumes. Each unit higher log-transformed NT-proBNP was associated with 3.6 mL (95% confidence interval [CI], -6.0 to -1.1) decline in TBV and 3.5 mL (95% CI, -5.7 to -1.3) decline in gray matter volume. Likewise, each millimeter higher CIMT was associated with 10.8 mL (95% CI, -17.3 to -4.2) decline in TBV and 8.6 mL (95% CI, -14.4 to -2.8) decline in gray matter volume. There was no association between NT-proBNP and CIMT and changes in white matter volume. Compared with participants with low NT-proBNP and CIMT, participants with both high NT-proBNP and CIMT had 3.8 mL (95% CI, -6.0 to -1.6) greater decline in their TBV and 4 mL (95% CI, -6.0 to -2.0) greater decline in GMW. These associations were independent of sociodemographic and cardiovascular factors. Conclusions - Older subjects with both cardiac dysfunction and carotid atherosclerosis are at an increased risk for brain parenchymal loss. Accumulated pathologies in the heart-brain axis might accelerate brain atrophy.

Original languageEnglish
Pages (from-to)2246-2251
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume36
Issue number11
DOIs
Publication statusPublished - 1 Nov 2016
Externally publishedYes

Fingerprint

Atrophy
Carotid Intima-Media Thickness
Brain
Confidence Intervals
Genes
Carotid Artery Diseases
Pathology
Brain Natriuretic Peptide
pro-brain natriuretic peptide (1-76)
Ultrasonography
Magnetic Resonance Imaging
Serum
Population
Gray Matter

Keywords

  • brain
  • brain natriuretic peptide
  • carotid stenosis
  • gray matter
  • white matter

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Cardiac and Carotid Markers Link with Accelerated Brain Atrophy : The AGES-Reykjavik Study (Age, Gene/Environment Susceptibility-Reykjavik). / Sabayan, Behnam; Van Buchem, Mark A.; Sigurdsson, Sigurdur; Zhang, Qian; Meirelles, Osorio; Harris, Tamara B.; Gudnason, Vilmundur; Arai, Andrew E.; Launer, Lenore J.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 36, No. 11, 01.11.2016, p. 2246-2251.

Research output: Contribution to journalArticle

Sabayan, Behnam ; Van Buchem, Mark A. ; Sigurdsson, Sigurdur ; Zhang, Qian ; Meirelles, Osorio ; Harris, Tamara B. ; Gudnason, Vilmundur ; Arai, Andrew E. ; Launer, Lenore J. / Cardiac and Carotid Markers Link with Accelerated Brain Atrophy : The AGES-Reykjavik Study (Age, Gene/Environment Susceptibility-Reykjavik). In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2016 ; Vol. 36, No. 11. pp. 2246-2251.
@article{d5ca8abe6c0044ae8105b6f2224b50c6,
title = "Cardiac and Carotid Markers Link with Accelerated Brain Atrophy: The AGES-Reykjavik Study (Age, Gene/Environment Susceptibility-Reykjavik)",
abstract = "Objective - Pathologies in the heart-brain axis might, independently or in combination, accelerate the process of brain parenchymal loss. We aimed to investigate the association of serum N-terminal brain natriuretic peptide (NT-proBNP), as a marker of cardiac dysfunction, and carotid intima media thickness (CIMT), as a marker of carotid atherosclerosis burden, with structural brain changes. Approach and Results - In the longitudinal population-based AGES-Reykjavik study (Age, Gene/Environment Susceptibility-Reykjavik), we included 2430 subjects (mean age, 74.6 years; 41.4{\%} men) with baseline data on NT-proBNP and CITM (assessed by ultrasound imaging). Participants underwent a high-resolution brain magnetic resonance imaging at baseline and 5 years later to assess total brain (TBV), gray matter, and white matter volumes. Each unit higher log-transformed NT-proBNP was associated with 3.6 mL (95{\%} confidence interval [CI], -6.0 to -1.1) decline in TBV and 3.5 mL (95{\%} CI, -5.7 to -1.3) decline in gray matter volume. Likewise, each millimeter higher CIMT was associated with 10.8 mL (95{\%} CI, -17.3 to -4.2) decline in TBV and 8.6 mL (95{\%} CI, -14.4 to -2.8) decline in gray matter volume. There was no association between NT-proBNP and CIMT and changes in white matter volume. Compared with participants with low NT-proBNP and CIMT, participants with both high NT-proBNP and CIMT had 3.8 mL (95{\%} CI, -6.0 to -1.6) greater decline in their TBV and 4 mL (95{\%} CI, -6.0 to -2.0) greater decline in GMW. These associations were independent of sociodemographic and cardiovascular factors. Conclusions - Older subjects with both cardiac dysfunction and carotid atherosclerosis are at an increased risk for brain parenchymal loss. Accumulated pathologies in the heart-brain axis might accelerate brain atrophy.",
keywords = "brain, brain natriuretic peptide, carotid stenosis, gray matter, white matter",
author = "Behnam Sabayan and {Van Buchem}, {Mark A.} and Sigurdur Sigurdsson and Qian Zhang and Osorio Meirelles and Harris, {Tamara B.} and Vilmundur Gudnason and Arai, {Andrew E.} and Launer, {Lenore J.}",
year = "2016",
month = "11",
day = "1",
doi = "10.1161/ATVBAHA.116.308018",
language = "English",
volume = "36",
pages = "2246--2251",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Cardiac and Carotid Markers Link with Accelerated Brain Atrophy

T2 - The AGES-Reykjavik Study (Age, Gene/Environment Susceptibility-Reykjavik)

AU - Sabayan, Behnam

AU - Van Buchem, Mark A.

AU - Sigurdsson, Sigurdur

AU - Zhang, Qian

AU - Meirelles, Osorio

AU - Harris, Tamara B.

AU - Gudnason, Vilmundur

AU - Arai, Andrew E.

AU - Launer, Lenore J.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Objective - Pathologies in the heart-brain axis might, independently or in combination, accelerate the process of brain parenchymal loss. We aimed to investigate the association of serum N-terminal brain natriuretic peptide (NT-proBNP), as a marker of cardiac dysfunction, and carotid intima media thickness (CIMT), as a marker of carotid atherosclerosis burden, with structural brain changes. Approach and Results - In the longitudinal population-based AGES-Reykjavik study (Age, Gene/Environment Susceptibility-Reykjavik), we included 2430 subjects (mean age, 74.6 years; 41.4% men) with baseline data on NT-proBNP and CITM (assessed by ultrasound imaging). Participants underwent a high-resolution brain magnetic resonance imaging at baseline and 5 years later to assess total brain (TBV), gray matter, and white matter volumes. Each unit higher log-transformed NT-proBNP was associated with 3.6 mL (95% confidence interval [CI], -6.0 to -1.1) decline in TBV and 3.5 mL (95% CI, -5.7 to -1.3) decline in gray matter volume. Likewise, each millimeter higher CIMT was associated with 10.8 mL (95% CI, -17.3 to -4.2) decline in TBV and 8.6 mL (95% CI, -14.4 to -2.8) decline in gray matter volume. There was no association between NT-proBNP and CIMT and changes in white matter volume. Compared with participants with low NT-proBNP and CIMT, participants with both high NT-proBNP and CIMT had 3.8 mL (95% CI, -6.0 to -1.6) greater decline in their TBV and 4 mL (95% CI, -6.0 to -2.0) greater decline in GMW. These associations were independent of sociodemographic and cardiovascular factors. Conclusions - Older subjects with both cardiac dysfunction and carotid atherosclerosis are at an increased risk for brain parenchymal loss. Accumulated pathologies in the heart-brain axis might accelerate brain atrophy.

AB - Objective - Pathologies in the heart-brain axis might, independently or in combination, accelerate the process of brain parenchymal loss. We aimed to investigate the association of serum N-terminal brain natriuretic peptide (NT-proBNP), as a marker of cardiac dysfunction, and carotid intima media thickness (CIMT), as a marker of carotid atherosclerosis burden, with structural brain changes. Approach and Results - In the longitudinal population-based AGES-Reykjavik study (Age, Gene/Environment Susceptibility-Reykjavik), we included 2430 subjects (mean age, 74.6 years; 41.4% men) with baseline data on NT-proBNP and CITM (assessed by ultrasound imaging). Participants underwent a high-resolution brain magnetic resonance imaging at baseline and 5 years later to assess total brain (TBV), gray matter, and white matter volumes. Each unit higher log-transformed NT-proBNP was associated with 3.6 mL (95% confidence interval [CI], -6.0 to -1.1) decline in TBV and 3.5 mL (95% CI, -5.7 to -1.3) decline in gray matter volume. Likewise, each millimeter higher CIMT was associated with 10.8 mL (95% CI, -17.3 to -4.2) decline in TBV and 8.6 mL (95% CI, -14.4 to -2.8) decline in gray matter volume. There was no association between NT-proBNP and CIMT and changes in white matter volume. Compared with participants with low NT-proBNP and CIMT, participants with both high NT-proBNP and CIMT had 3.8 mL (95% CI, -6.0 to -1.6) greater decline in their TBV and 4 mL (95% CI, -6.0 to -2.0) greater decline in GMW. These associations were independent of sociodemographic and cardiovascular factors. Conclusions - Older subjects with both cardiac dysfunction and carotid atherosclerosis are at an increased risk for brain parenchymal loss. Accumulated pathologies in the heart-brain axis might accelerate brain atrophy.

KW - brain

KW - brain natriuretic peptide

KW - carotid stenosis

KW - gray matter

KW - white matter

UR - http://www.scopus.com/inward/record.url?scp=84986210663&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84986210663&partnerID=8YFLogxK

U2 - 10.1161/ATVBAHA.116.308018

DO - 10.1161/ATVBAHA.116.308018

M3 - Article

VL - 36

SP - 2246

EP - 2251

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 11

ER -