Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa

B. J. Feng, M. Khyatti, W. Ben-Ayoub, S. Dahmoul, M. Ayad, F. Maachi, W. Bedadra, M. Abdoun, S. Mesli, H. Bakkali, M. Jalbout, M. Hamdi-Cherif, K. Boualga, N. Bouaouina, Lotfi Chouchane, A. Benider, F. Ben-Ayed, D. E. Goldgar, M. Corbex

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Background: The lifestyle risk factors for nasopharyngeal carcinoma (NPC) in North Africa are not known. Methods: From 2002 to 2005, we interviewed 636 patients and 615 controls from Algeria, Morocco and Tunisia, frequency-matched by centre, age, sex, and childhood household type (urban/rural). Conditional logistic regression was used to evaluate the association of lifestyles with NPC risk, controlling for socioeconomic status and dietary risk factors. Results: Cigarette smoking and snuff (tobacco powder with additives) intake were significantly associated with differentiated NPC but not with undifferentiated carcinoma (UCNT), which is the major histological type of NPC in these populations. As demonstrated by a stratified permutation test and by conditional logistic regression, marijuana smoking significantly elevated NPC risk independently of cigarette smoking, suggesting dissimilar carcinogenic mechanisms between cannabis and tobacco. Domestic cooking fumes intake by using kanoun (compact charcoal oven) during childhood increased NPC risk, whereas exposure during adulthood had less effect. Neither alcohol nor shisha (water pipe) was associated with risk. Conclusion: Tobacco, cannabis and domestic cooking fumes intake are risk factors for NPC in western North Africa.

Original languageEnglish
Pages (from-to)1207-1212
Number of pages6
JournalBritish Journal of Cancer
Volume101
Issue number7
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

Northern Africa
Cannabis
Tobacco
Cooking
Life Style
Logistic Models
Smoking
Marijuana Smoking
Algeria
Smokeless Tobacco
Morocco
Tunisia
Western Africa
Charcoal
Nasopharyngeal carcinoma
Social Class
Powders
Alcohols
Carcinoma
Water

Keywords

  • Cannabis
  • Fumes
  • Nasopharyngeal carcinoma
  • North Africa
  • Tobacco

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Feng, B. J., Khyatti, M., Ben-Ayoub, W., Dahmoul, S., Ayad, M., Maachi, F., ... Corbex, M. (2009). Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa. British Journal of Cancer, 101(7), 1207-1212. https://doi.org/10.1038/sj.bjc.6605281

Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa. / Feng, B. J.; Khyatti, M.; Ben-Ayoub, W.; Dahmoul, S.; Ayad, M.; Maachi, F.; Bedadra, W.; Abdoun, M.; Mesli, S.; Bakkali, H.; Jalbout, M.; Hamdi-Cherif, M.; Boualga, K.; Bouaouina, N.; Chouchane, Lotfi; Benider, A.; Ben-Ayed, F.; Goldgar, D. E.; Corbex, M.

In: British Journal of Cancer, Vol. 101, No. 7, 2009, p. 1207-1212.

Research output: Contribution to journalArticle

Feng, BJ, Khyatti, M, Ben-Ayoub, W, Dahmoul, S, Ayad, M, Maachi, F, Bedadra, W, Abdoun, M, Mesli, S, Bakkali, H, Jalbout, M, Hamdi-Cherif, M, Boualga, K, Bouaouina, N, Chouchane, L, Benider, A, Ben-Ayed, F, Goldgar, DE & Corbex, M 2009, 'Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa', British Journal of Cancer, vol. 101, no. 7, pp. 1207-1212. https://doi.org/10.1038/sj.bjc.6605281
Feng, B. J. ; Khyatti, M. ; Ben-Ayoub, W. ; Dahmoul, S. ; Ayad, M. ; Maachi, F. ; Bedadra, W. ; Abdoun, M. ; Mesli, S. ; Bakkali, H. ; Jalbout, M. ; Hamdi-Cherif, M. ; Boualga, K. ; Bouaouina, N. ; Chouchane, Lotfi ; Benider, A. ; Ben-Ayed, F. ; Goldgar, D. E. ; Corbex, M. / Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa. In: British Journal of Cancer. 2009 ; Vol. 101, No. 7. pp. 1207-1212.
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abstract = "Background: The lifestyle risk factors for nasopharyngeal carcinoma (NPC) in North Africa are not known. Methods: From 2002 to 2005, we interviewed 636 patients and 615 controls from Algeria, Morocco and Tunisia, frequency-matched by centre, age, sex, and childhood household type (urban/rural). Conditional logistic regression was used to evaluate the association of lifestyles with NPC risk, controlling for socioeconomic status and dietary risk factors. Results: Cigarette smoking and snuff (tobacco powder with additives) intake were significantly associated with differentiated NPC but not with undifferentiated carcinoma (UCNT), which is the major histological type of NPC in these populations. As demonstrated by a stratified permutation test and by conditional logistic regression, marijuana smoking significantly elevated NPC risk independently of cigarette smoking, suggesting dissimilar carcinogenic mechanisms between cannabis and tobacco. Domestic cooking fumes intake by using kanoun (compact charcoal oven) during childhood increased NPC risk, whereas exposure during adulthood had less effect. Neither alcohol nor shisha (water pipe) was associated with risk. Conclusion: Tobacco, cannabis and domestic cooking fumes intake are risk factors for NPC in western North Africa.",
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AU - Ayad, M.

AU - Maachi, F.

AU - Bedadra, W.

AU - Abdoun, M.

AU - Mesli, S.

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AU - Boualga, K.

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AU - Ben-Ayed, F.

AU - Goldgar, D. E.

AU - Corbex, M.

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