Candidate genes for panic disorder

Insight from human and mouse genetic studies

M. Gratacòs, I. Sahún, X. Gallego, A. Amador-Arjona, Xavier P. Estivill, M. Dierssen

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Panic disorder is a major cause of medical attention with substantial social and health service cost. Based on pharmacological studies, research on its etiopathogenesis has been focused on the possible dysfunction of specific neurotransmitter systems. However, recent work has related the genes involved in development, synaptic plasticity and synaptic remodeling to anxiety disorders. This implies that learning processes and changes in perception, interpretation and behavioral responses to environmental stimuli are essential for development of complex anxiety responses secondary to the building of specific brain neural circuits and to adult plasticity. The focus of this review is on progress achieved in identifying genes that confer increased risk for panic disorder through genetic epidemiology and the use of genetically modified mouse models. The integration of human and animal studies targeting behavioral, systems-level, cellular and molecular levels will most probably help identify new molecules with potential impact on the pathogenetic aspects of the disease.

Original languageEnglish
Pages (from-to)2-23
Number of pages22
JournalGenes, Brain and Behavior
Volume6
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jun 2007
Externally publishedYes

Fingerprint

Panic Disorder
Medical Genetics
Neuronal Plasticity
Molecular Epidemiology
Anxiety Disorders
Social Work
Health Care Costs
Genes
Health Services
Neurotransmitter Agents
Anxiety
Learning
Pharmacology
Brain
Research

Keywords

  • Anxiety disorder
  • BDNF
  • Fear
  • Mouse models
  • Neurotrophin
  • NT-3
  • Panic disorder

ASJC Scopus subject areas

  • Neuroscience(all)
  • Genetics

Cite this

Candidate genes for panic disorder : Insight from human and mouse genetic studies. / Gratacòs, M.; Sahún, I.; Gallego, X.; Amador-Arjona, A.; Estivill, Xavier P.; Dierssen, M.

In: Genes, Brain and Behavior, Vol. 6, No. SUPPL. 1, 06.2007, p. 2-23.

Research output: Contribution to journalReview article

Gratacòs, M, Sahún, I, Gallego, X, Amador-Arjona, A, Estivill, XP & Dierssen, M 2007, 'Candidate genes for panic disorder: Insight from human and mouse genetic studies', Genes, Brain and Behavior, vol. 6, no. SUPPL. 1, pp. 2-23. https://doi.org/10.1111/j.1601-183X.2007.00318.x
Gratacòs, M. ; Sahún, I. ; Gallego, X. ; Amador-Arjona, A. ; Estivill, Xavier P. ; Dierssen, M. / Candidate genes for panic disorder : Insight from human and mouse genetic studies. In: Genes, Brain and Behavior. 2007 ; Vol. 6, No. SUPPL. 1. pp. 2-23.
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