Calreticulin

One protein, one gene, many functions

Marek Michalak, Elaine F. Corbett, Nasrin Mesaeli, Kimitoshi Nakamura, Michal Opas

Research output: Contribution to journalReview article

588 Citations (Scopus)

Abstract

The endoplasmic reticulum (ER) plays a critical role in the synthesis and chaperoning of membrane-associated and secreted proteins. The membrane is also an important site of Ca2+ storage and release. Calreticulin is a unique ER luminal resident protein. The protein affects many cellular functions, both in the ER lumen and outside of the ER environment. In the ER lumen, calreticulin performs two major functions: chaperoning and regulation of Ca2+ homoeostasis. Calreticulin is a highly versatile lectin-like chaperone, and it participates during the synthesis of a variety of molecules, including ion channels, surface receptors, integrins and transporters. The protein also affects intracellular Ca2+ homoeostasis by modulation of ER Ca2+ storage and transport. Studies on the cell biology of calreticulin revealed that the ER membrane is a very dynamic intracellular compartment affecting many aspects of cell physiology.

Original languageEnglish
Pages (from-to)281-292
Number of pages12
JournalBiochemical Journal
Volume344
Issue number2
DOIs
Publication statusPublished - 1 Dec 1999
Externally publishedYes

Fingerprint

Calreticulin
Endoplasmic Reticulum
Genes
Membranes
Proteins
Cytology
Physiology
Ion Channels
Lectins
Integrins
Homeostasis
Cell Physiological Phenomena
Modulation
Molecules
Cell Biology
Membrane Proteins

Keywords

  • Ca homoeostasis
  • Chaperoning
  • Endoplasmic reticulum
  • Luminal resident protein
  • Membranes

ASJC Scopus subject areas

  • Biochemistry

Cite this

Michalak, M., Corbett, E. F., Mesaeli, N., Nakamura, K., & Opas, M. (1999). Calreticulin: One protein, one gene, many functions. Biochemical Journal, 344(2), 281-292. https://doi.org/10.1042/0264-6021:3440281

Calreticulin : One protein, one gene, many functions. / Michalak, Marek; Corbett, Elaine F.; Mesaeli, Nasrin; Nakamura, Kimitoshi; Opas, Michal.

In: Biochemical Journal, Vol. 344, No. 2, 01.12.1999, p. 281-292.

Research output: Contribution to journalReview article

Michalak, M, Corbett, EF, Mesaeli, N, Nakamura, K & Opas, M 1999, 'Calreticulin: One protein, one gene, many functions', Biochemical Journal, vol. 344, no. 2, pp. 281-292. https://doi.org/10.1042/0264-6021:3440281
Michalak, Marek ; Corbett, Elaine F. ; Mesaeli, Nasrin ; Nakamura, Kimitoshi ; Opas, Michal. / Calreticulin : One protein, one gene, many functions. In: Biochemical Journal. 1999 ; Vol. 344, No. 2. pp. 281-292.
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