Calcium sensing receptor and renal mineral ion transport.

F. Rainone, T. Arcidiacono, Annalisa Terranegra, A. Aloia, E. Dogliotti, A. Mingione, D. Spotti, C. M. Francucci, L. Soldati, G. Vezzoli

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Calcium sensing receptor (CaSR) is a component of the C family of the G protein-coupled receptors. It is ubiquitously expressed in human and mammal cells but is more expressed in parathyroid glands and kidney cells. It is located on the cell plasma membrane and senses the changes of extracellular calcium concentrations. Thus, it may modify cell functions according to serum calcium levels. CaSR has a key role in calcium homeostasis because it allows parathyroid glands and kidney to regulate PTH secretion and calcium reabsorption in order to keep serum calcium concentration within the normal range. CaSR appears as an important player in the regulation of renal calcium handling and body calcium metabolism. Thus, CaSR may protect human tissues against calcium excess. In kidneys, its protective effect includes the stimulation of diuresis and phosphate retention, along with the potential prevention of calcium precipitation and deposition in kidney tubules and interstitium.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalJournal of Endocrinological Investigation
Volume34
Issue number7 Suppl
Publication statusPublished - Jul 2011
Externally publishedYes

Fingerprint

Calcium-Sensing Receptors
Ion Transport
Minerals
Calcium
Kidney
Parathyroid Glands
Cell Membrane
Kidney Tubules
Diuresis
G-Protein-Coupled Receptors
Serum
Mammals
Reference Values
Homeostasis
Phosphates

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Rainone, F., Arcidiacono, T., Terranegra, A., Aloia, A., Dogliotti, E., Mingione, A., ... Vezzoli, G. (2011). Calcium sensing receptor and renal mineral ion transport. Journal of Endocrinological Investigation, 34(7 Suppl), 8-12.

Calcium sensing receptor and renal mineral ion transport. / Rainone, F.; Arcidiacono, T.; Terranegra, Annalisa; Aloia, A.; Dogliotti, E.; Mingione, A.; Spotti, D.; Francucci, C. M.; Soldati, L.; Vezzoli, G.

In: Journal of Endocrinological Investigation, Vol. 34, No. 7 Suppl, 07.2011, p. 8-12.

Research output: Contribution to journalReview article

Rainone, F, Arcidiacono, T, Terranegra, A, Aloia, A, Dogliotti, E, Mingione, A, Spotti, D, Francucci, CM, Soldati, L & Vezzoli, G 2011, 'Calcium sensing receptor and renal mineral ion transport.', Journal of Endocrinological Investigation, vol. 34, no. 7 Suppl, pp. 8-12.
Rainone F, Arcidiacono T, Terranegra A, Aloia A, Dogliotti E, Mingione A et al. Calcium sensing receptor and renal mineral ion transport. Journal of Endocrinological Investigation. 2011 Jul;34(7 Suppl):8-12.
Rainone, F. ; Arcidiacono, T. ; Terranegra, Annalisa ; Aloia, A. ; Dogliotti, E. ; Mingione, A. ; Spotti, D. ; Francucci, C. M. ; Soldati, L. ; Vezzoli, G. / Calcium sensing receptor and renal mineral ion transport. In: Journal of Endocrinological Investigation. 2011 ; Vol. 34, No. 7 Suppl. pp. 8-12.
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