Calcium ([Ca2+]I ) signaling as a key-target for cancer treatment

Ana Maria Florea, Dietrich Busselberg

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer represents a major field of investigation for the modern medicine. Anti-cancer drugs induce tumor cell death. While some anti-cancer drugs are genotoxic, directly targeting nucleic acids, others interfere with the signaling pathways to trigger programmed cell death. For the induction and the execution of apoptosis, intracellular calcium signals are important. Much interest is now oriented in discovering new combinatorial strategies that are now tested in clinical trials in order to improve standard procedures. Our results indicate that cisplatin (cis-di-amino-dichloride-platin) and arsenic trioxide modify intracellular Ca2+ by different mechanisms, supporting the hypothesis that calcium signaling plays an important role in chemical-induced neuroblastoma cell toxicity. In addition, understanding how specific drug combinations work to result in enhanced effects on neuroblastoma cell death might represent a new therapeutic strategy for neuroblastoma as well as ways to overcome drug resistance. There may be a strong link between drug resistance, cell death and changes in intracellular Ca2+ . Future experiments have to identify the specific mechanisms to illuminate possible targets and to override drug resistance.

Original languageEnglish
Title of host publicationCalcium Signaling
PublisherNova Science Publishers, Inc.
Pages215-220
Number of pages6
ISBN (Print)9781613243138
Publication statusPublished - Feb 2012

Fingerprint

Oncology
Cell death
Cell Death
Neuroblastoma
Drug Resistance
Calcium
Pharmaceutical Preparations
Neoplasms
Modern 1601-history
Calcium Signaling
Drug Combinations
Nucleic Acids
Clinical Trials
Medicine
Toxicity
Apoptosis
Tumors
Experiments
Therapeutics

Keywords

  • Apoptosis
  • Arsenic trioxide
  • Calcium signaling
  • Cancer
  • Cancer therapy
  • Cisplatin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Florea, A. M., & Busselberg, D. (2012). Calcium ([Ca2+]I ) signaling as a key-target for cancer treatment. In Calcium Signaling (pp. 215-220). Nova Science Publishers, Inc..

Calcium ([Ca2+]I ) signaling as a key-target for cancer treatment. / Florea, Ana Maria; Busselberg, Dietrich.

Calcium Signaling. Nova Science Publishers, Inc., 2012. p. 215-220.

Research output: Chapter in Book/Report/Conference proceedingChapter

Florea, AM & Busselberg, D 2012, Calcium ([Ca2+]I ) signaling as a key-target for cancer treatment. in Calcium Signaling. Nova Science Publishers, Inc., pp. 215-220.
Florea AM, Busselberg D. Calcium ([Ca2+]I ) signaling as a key-target for cancer treatment. In Calcium Signaling. Nova Science Publishers, Inc. 2012. p. 215-220
Florea, Ana Maria ; Busselberg, Dietrich. / Calcium ([Ca2+]I ) signaling as a key-target for cancer treatment. Calcium Signaling. Nova Science Publishers, Inc., 2012. pp. 215-220
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