Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant

Daniel E. Platt, Michella Ghassibe-Sabbagh, Pascale Salameh, Angelique K. Salloum, Marc Haber, Francis Mouzaya, Dominique Gauguier, Yaser Al-Sarraj, Hatem El-Shanti, Pierre A. Zalloua, Antoine B. Abchee

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Cultural, dietary, and lifestyle factors are the main modulators of type 2 diabetes mellitus (T2DM) disease risk. Coffee is one of the most popular worldwide beverages, and recent epidemiological studies have showed that coffee consumption is associated with a lower risk of T2DM. This study investigates the impact of coffee intake on T2DM risk and assesses the effect of CYP variants with caffeine exposures on T2DM. Data from 7,607 study subjects were analyzed by logistic regression models, among whom 3,290 GWAS data were available for CYP variants association studies using Plink analysis. These data suggest a protective relationship for women, but not for men; however, the results were not statistically significant in this dataset and there is a significant interaction in favor of women regarding heavy coffee consumption. The interaction between male gender and heavy coffee consumption becomes significant, thereby tending to cancel the protective effect of coffee for males. CYP rs2470890 allele ‘C' increases the odds of T2DM by a factor of around 1.2 but decreases the odds of caffeine boosting T2DM of 1.7 by a factor of 0.77. rs2470890 showed an association with T2DM only when the interaction with coffee was considered, thereby setting an example of genetic activation by dietary changes associating with metabolic syndrome.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalAnnals of Nutrition and Metabolism
DOIs
Publication statusAccepted/In press - 21 Nov 2015

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Cytochrome P-450 CYP1A2
Coffee
Caffeine
Type 2 Diabetes Mellitus
Logistic Models
Genome-Wide Association Study
Beverages
Life Style
Epidemiologic Studies
Alleles

Keywords

  • Diabetes
  • Diet and foods
  • Gene nutrient interaction#

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Platt, D. E., Ghassibe-Sabbagh, M., Salameh, P., Salloum, A. K., Haber, M., Mouzaya, F., ... Abchee, A. B. (Accepted/In press). Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant. Annals of Nutrition and Metabolism, 1-11. https://doi.org/10.1159/000441481

Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant. / Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Salameh, Pascale; Salloum, Angelique K.; Haber, Marc; Mouzaya, Francis; Gauguier, Dominique; Al-Sarraj, Yaser; El-Shanti, Hatem; Zalloua, Pierre A.; Abchee, Antoine B.

In: Annals of Nutrition and Metabolism, 21.11.2015, p. 1-11.

Research output: Contribution to journalArticle

Platt, DE, Ghassibe-Sabbagh, M, Salameh, P, Salloum, AK, Haber, M, Mouzaya, F, Gauguier, D, Al-Sarraj, Y, El-Shanti, H, Zalloua, PA & Abchee, AB 2015, 'Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant', Annals of Nutrition and Metabolism, pp. 1-11. https://doi.org/10.1159/000441481
Platt DE, Ghassibe-Sabbagh M, Salameh P, Salloum AK, Haber M, Mouzaya F et al. Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant. Annals of Nutrition and Metabolism. 2015 Nov 21;1-11. https://doi.org/10.1159/000441481
Platt, Daniel E. ; Ghassibe-Sabbagh, Michella ; Salameh, Pascale ; Salloum, Angelique K. ; Haber, Marc ; Mouzaya, Francis ; Gauguier, Dominique ; Al-Sarraj, Yaser ; El-Shanti, Hatem ; Zalloua, Pierre A. ; Abchee, Antoine B. / Caffeine Impact on Metabolic Syndrome Components Is Modulated by a CYP1A2 Variant. In: Annals of Nutrition and Metabolism. 2015 ; pp. 1-11.
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