C1q/TNF-related protein-3 and glucose homeostasis

Habib Yaribeygi, Farin Rashidfarrokhi, Stephen Atkin, Amirhossein Sahebkar

Research output: Contribution to journalReview article


Adipokines are cytokines produced by adipocytes that may mediate inflammatory processes, whilst adipocyte-derived proteins may have the converse effect. C1q/TNF-related protein-3 or CTRP3 is a novel adipokine that is expressed and released by most types of human tissues including adipose tissue. This adipokine, considered as an adiponectin, can normalize blood glucose by several mechanisms. In addition, it can modulate the expression/secretion of other cytokine and adipokines leading to lower insulin resistance in peripheral tissues. Beneficial effects of CTRP3 against hyperglycemia-induced complications in the kidney and eye have been reported. In this review, we have presented the latest findings on the in vitro and in vivo hypoglycemic effects of CTRP3, followed by the findings on the preventive/therapeutic effects of CTRP3 adipokines against diabetes related complications.

Original languageEnglish
Pages (from-to)1923-1927
Number of pages5
JournalDiabetes and Metabolic Syndrome: Clinical Research and Reviews
Issue number3
Publication statusPublished - 1 May 2019



  • Adipokine
  • Adiponectin
  • C1q/TNF-Related protein-3
  • CTRP3
  • Glut-4
  • Inflammation
  • Insulin resistance
  • Insulin sensitivity
  • TNF-α

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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