Breast cancer in arab populations

Molecular characteristics and disease management implications

Research output: Contribution to journalReview article

57 Citations (Scopus)

Abstract

Breast cancer is a major health problem in both developing and developed countries. It is the most frequently diagnosed female malignant disease in Arab populations. The incidence of breast cancer is lower in Arab countries than in Europe and the USA but is rising fast. Breast cancers in women from Arab populations have different characteristics to those reported in individuals from Europe and the USA. For example, affected patients are at least a decade younger, they have a more advanced stage of disease at first presentation, and their tumour size is larger. Moreover, in some Arab populations, reports suggest increased axillary-lymph-node invasion, a larger proportion of negative hormone receptors, and a higher tumour grade. These disparities are not only confined to clinicopathological features but also exist at the molecular level, as shown by findings of genome-wide association studies and expression profiling.

Original languageEnglish
JournalThe Lancet Oncology
Volume14
Issue number10
DOIs
Publication statusPublished - Sep 2013

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Population Characteristics
Disease Management
Breast Neoplasms
Population
Middle East
Genome-Wide Association Study
Developed Countries
Developing Countries
Neoplasms
Lymph Nodes
Hormones
Incidence
Health

ASJC Scopus subject areas

  • Oncology

Cite this

Breast cancer in arab populations : Molecular characteristics and disease management implications. / Chouchane, Lotfi; Boussen, Hammouda; Konduru, Seetharama S.

In: The Lancet Oncology, Vol. 14, No. 10, 09.2013.

Research output: Contribution to journalReview article

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