Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder

Steven H. Woodward, Danny G. Kaloupek, Chris C. Streeter, Matthew O. Kimble, Allan L. Reiss, Stephan Eliez, Lawrence L. Wald, Perry F. Renshaw, Blaise B. Frederick, Barton Lane, Javaid I. Sheikh, Wendy K. Stegman, Catherine J. Kutter, Lorraine P. Stewart, Rebecca S. Prestel, Ned J. Arsenault

Research output: Contribution to journalArticle

16 Citations (Scopus)


Children and adolescents with maltreatment-related posttraumatic stress disorder (PTSD) exhibit smaller intracranial tissue volume than controls. Linear relationships have also been observed between intracranial tissue volume and the age of maltreatment onset. The authors explored associations among adult PTSD, early trauma, and cerebral volumes in 99 combat veterans. A bone-based estimate of cranial volume was developed to adjust for variation in body size. Posttraumatic stress disorder was not associated with smaller cerebral tissue volume, but rather with smaller cerebrospinal fluid (CSF) and cranial volumes. These findings co-occurred with expected effects of alcoholism and aging on cerebral tissue and CSF volumes. The results point to early developmental divergences between groups with and without PTSD following adult trauma.

Original languageEnglish
Pages (from-to)763-774
Number of pages12
JournalJournal of Traumatic Stress
Issue number5
Publication statusPublished - 1 Oct 2007


ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

Woodward, S. H., Kaloupek, D. G., Streeter, C. C., Kimble, M. O., Reiss, A. L., Eliez, S., Wald, L. L., Renshaw, P. F., Frederick, B. B., Lane, B., Sheikh, J. I., Stegman, W. K., Kutter, C. J., Stewart, L. P., Prestel, R. S., & Arsenault, N. J. (2007). Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder. Journal of Traumatic Stress, 20(5), 763-774.