Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder

Steven H. Woodward, Danny G. Kaloupek, Chris C. Streeter, Matthew O. Kimble, Allan L. Reiss, Stephan Eliez, Lawrence L. Wald, Perry F. Renshaw, Blaise B. Frederick, Barton Lane, Javaid Sheikh, Wendy K. Stegman, Catherine J. Kutter, Lorraine P. Stewart, Rebecca S. Prestel, Ned J. Arsenault

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Children and adolescents with maltreatment-related posttraumatic stress disorder (PTSD) exhibit smaller intracranial tissue volume than controls. Linear relationships have also been observed between intracranial tissue volume and the age of maltreatment onset. The authors explored associations among adult PTSD, early trauma, and cerebral volumes in 99 combat veterans. A bone-based estimate of cranial volume was developed to adjust for variation in body size. Posttraumatic stress disorder was not associated with smaller cerebral tissue volume, but rather with smaller cerebrospinal fluid (CSF) and cranial volumes. These findings co-occurred with expected effects of alcoholism and aging on cerebral tissue and CSF volumes. The results point to early developmental divergences between groups with and without PTSD following adult trauma.

Original languageEnglish
Pages (from-to)763-774
Number of pages12
JournalJournal of Traumatic Stress
Volume20
Issue number5
DOIs
Publication statusPublished - Oct 2007
Externally publishedYes

Fingerprint

Post-Traumatic Stress Disorders
Skull
Cerebrospinal Fluid
Brain
Wounds and Injuries
Body Size
Veterans
Age of Onset
Alcoholism
Bone and Bones

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Psychology(all)
  • Clinical Psychology

Cite this

Woodward, S. H., Kaloupek, D. G., Streeter, C. C., Kimble, M. O., Reiss, A. L., Eliez, S., ... Arsenault, N. J. (2007). Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder. Journal of Traumatic Stress, 20(5), 763-774. https://doi.org/10.1002/jts.20241

Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder. / Woodward, Steven H.; Kaloupek, Danny G.; Streeter, Chris C.; Kimble, Matthew O.; Reiss, Allan L.; Eliez, Stephan; Wald, Lawrence L.; Renshaw, Perry F.; Frederick, Blaise B.; Lane, Barton; Sheikh, Javaid; Stegman, Wendy K.; Kutter, Catherine J.; Stewart, Lorraine P.; Prestel, Rebecca S.; Arsenault, Ned J.

In: Journal of Traumatic Stress, Vol. 20, No. 5, 10.2007, p. 763-774.

Research output: Contribution to journalArticle

Woodward, SH, Kaloupek, DG, Streeter, CC, Kimble, MO, Reiss, AL, Eliez, S, Wald, LL, Renshaw, PF, Frederick, BB, Lane, B, Sheikh, J, Stegman, WK, Kutter, CJ, Stewart, LP, Prestel, RS & Arsenault, NJ 2007, 'Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder', Journal of Traumatic Stress, vol. 20, no. 5, pp. 763-774. https://doi.org/10.1002/jts.20241
Woodward SH, Kaloupek DG, Streeter CC, Kimble MO, Reiss AL, Eliez S et al. Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder. Journal of Traumatic Stress. 2007 Oct;20(5):763-774. https://doi.org/10.1002/jts.20241
Woodward, Steven H. ; Kaloupek, Danny G. ; Streeter, Chris C. ; Kimble, Matthew O. ; Reiss, Allan L. ; Eliez, Stephan ; Wald, Lawrence L. ; Renshaw, Perry F. ; Frederick, Blaise B. ; Lane, Barton ; Sheikh, Javaid ; Stegman, Wendy K. ; Kutter, Catherine J. ; Stewart, Lorraine P. ; Prestel, Rebecca S. ; Arsenault, Ned J. / Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder. In: Journal of Traumatic Stress. 2007 ; Vol. 20, No. 5. pp. 763-774.
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