Bovine lactoferrin and lactoferricin interfere with intracellular trafficking of Herpes simplex virus-1

A. K. Marr, H. Jenssen, M. Roshan Moniri, R. E.W. Hancock, N. Panté

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Although both lactoferrin (Lf), a component of the innate immune system of living organisms, and its N-terminal pepsin cleavage product lactoferricin (Lfcin) have anti-herpes activity, the precise mechanisms by which Lf and Lfcin bring about inhibition of herpes infections are not fully understood. In the present study, experiments were carried out to characterize the activity of bovine Lf and Lfcin (BLf and BLfcin) against the Herpes simplex virus-1 (HSV-1). HSV-1 cellular uptake and intracellular trafficking were studied by immunofluorescence microscopy. In comparison to the untreated infected control cells, both the BLf- and BLfcin-treated cells showed a significant reduction in HSV-1 cellular uptake. The few virus particles that were internalized appeared to have a delayed intracellular trafficking. Thus, in addition to their interference with the uptake of the virus into host cells, Lf and Lfcin also exert their antiviral effect intracellularly.

Original languageEnglish
Pages (from-to)160-164
Number of pages5
JournalBiochimie
Volume91
Issue number1
DOIs
Publication statusPublished - 1 Jan 2009

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Keywords

  • Antiviral
  • HSV-1
  • Herpes virus
  • Lactoferricin
  • Lactoferrin

ASJC Scopus subject areas

  • Biochemistry

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