Blood transcriptional fingerprints to assess the immune status of human subjects

Damien J. Chaussabel, Nicole Baldwin, Derek Blankenship, Charles Quinn, Esperanza Anguiano, Octavio Ramilo, Ganjana Lertmemongkolchai, Virginia Pascual, Jacques Banchereau

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The blood transcriptome affords a comprehensive view of the status of the human immune system. Global changes in transcript abundance have been measured in the blood of patients with a wide range of diseases. This chapter presents an overview of the advances that have led to the identification of therapeutic targets and biomarker signatures in the field of autoimmunity and infectious disease. It also provides technology and data analysis primers as means of introducing blood transcriptome research to a broad readership. Specifically, we compare microarrays with some of the most recent digital gene expression profiling technologies available to date, including RNA sequencing. Furthermore, in addition to the basic steps involved in the analysis of microarray data we also present more advanced data mining approaches for blood transcriptional fingerprinting.

Original languageEnglish
Title of host publicationImmunologic Signatures of Rejection
PublisherSpringer New York
Pages105-125
Number of pages21
ISBN (Electronic)9781441972194
ISBN (Print)9781441972187
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Dermatoglyphics
Transcriptome
Technology
RNA Sequence Analysis
Data Mining
Gene Expression Profiling
Microarray Analysis
Autoimmunity
Communicable Diseases
Immune System
Biomarkers
Research
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Chaussabel, D. J., Baldwin, N., Blankenship, D., Quinn, C., Anguiano, E., Ramilo, O., ... Banchereau, J. (2011). Blood transcriptional fingerprints to assess the immune status of human subjects. In Immunologic Signatures of Rejection (pp. 105-125). Springer New York. https://doi.org/10.1007/978-1-4419-7219-4_8

Blood transcriptional fingerprints to assess the immune status of human subjects. / Chaussabel, Damien J.; Baldwin, Nicole; Blankenship, Derek; Quinn, Charles; Anguiano, Esperanza; Ramilo, Octavio; Lertmemongkolchai, Ganjana; Pascual, Virginia; Banchereau, Jacques.

Immunologic Signatures of Rejection. Springer New York, 2011. p. 105-125.

Research output: Chapter in Book/Report/Conference proceedingChapter

Chaussabel, DJ, Baldwin, N, Blankenship, D, Quinn, C, Anguiano, E, Ramilo, O, Lertmemongkolchai, G, Pascual, V & Banchereau, J 2011, Blood transcriptional fingerprints to assess the immune status of human subjects. in Immunologic Signatures of Rejection. Springer New York, pp. 105-125. https://doi.org/10.1007/978-1-4419-7219-4_8
Chaussabel DJ, Baldwin N, Blankenship D, Quinn C, Anguiano E, Ramilo O et al. Blood transcriptional fingerprints to assess the immune status of human subjects. In Immunologic Signatures of Rejection. Springer New York. 2011. p. 105-125 https://doi.org/10.1007/978-1-4419-7219-4_8
Chaussabel, Damien J. ; Baldwin, Nicole ; Blankenship, Derek ; Quinn, Charles ; Anguiano, Esperanza ; Ramilo, Octavio ; Lertmemongkolchai, Ganjana ; Pascual, Virginia ; Banchereau, Jacques. / Blood transcriptional fingerprints to assess the immune status of human subjects. Immunologic Signatures of Rejection. Springer New York, 2011. pp. 105-125
@inbook{f1c524c3de7d44e6882f113f20420b4e,
title = "Blood transcriptional fingerprints to assess the immune status of human subjects",
abstract = "The blood transcriptome affords a comprehensive view of the status of the human immune system. Global changes in transcript abundance have been measured in the blood of patients with a wide range of diseases. This chapter presents an overview of the advances that have led to the identification of therapeutic targets and biomarker signatures in the field of autoimmunity and infectious disease. It also provides technology and data analysis primers as means of introducing blood transcriptome research to a broad readership. Specifically, we compare microarrays with some of the most recent digital gene expression profiling technologies available to date, including RNA sequencing. Furthermore, in addition to the basic steps involved in the analysis of microarray data we also present more advanced data mining approaches for blood transcriptional fingerprinting.",
author = "Chaussabel, {Damien J.} and Nicole Baldwin and Derek Blankenship and Charles Quinn and Esperanza Anguiano and Octavio Ramilo and Ganjana Lertmemongkolchai and Virginia Pascual and Jacques Banchereau",
year = "2011",
doi = "10.1007/978-1-4419-7219-4_8",
language = "English",
isbn = "9781441972187",
pages = "105--125",
booktitle = "Immunologic Signatures of Rejection",
publisher = "Springer New York",

}

TY - CHAP

T1 - Blood transcriptional fingerprints to assess the immune status of human subjects

AU - Chaussabel, Damien J.

AU - Baldwin, Nicole

AU - Blankenship, Derek

AU - Quinn, Charles

AU - Anguiano, Esperanza

AU - Ramilo, Octavio

AU - Lertmemongkolchai, Ganjana

AU - Pascual, Virginia

AU - Banchereau, Jacques

PY - 2011

Y1 - 2011

N2 - The blood transcriptome affords a comprehensive view of the status of the human immune system. Global changes in transcript abundance have been measured in the blood of patients with a wide range of diseases. This chapter presents an overview of the advances that have led to the identification of therapeutic targets and biomarker signatures in the field of autoimmunity and infectious disease. It also provides technology and data analysis primers as means of introducing blood transcriptome research to a broad readership. Specifically, we compare microarrays with some of the most recent digital gene expression profiling technologies available to date, including RNA sequencing. Furthermore, in addition to the basic steps involved in the analysis of microarray data we also present more advanced data mining approaches for blood transcriptional fingerprinting.

AB - The blood transcriptome affords a comprehensive view of the status of the human immune system. Global changes in transcript abundance have been measured in the blood of patients with a wide range of diseases. This chapter presents an overview of the advances that have led to the identification of therapeutic targets and biomarker signatures in the field of autoimmunity and infectious disease. It also provides technology and data analysis primers as means of introducing blood transcriptome research to a broad readership. Specifically, we compare microarrays with some of the most recent digital gene expression profiling technologies available to date, including RNA sequencing. Furthermore, in addition to the basic steps involved in the analysis of microarray data we also present more advanced data mining approaches for blood transcriptional fingerprinting.

UR - http://www.scopus.com/inward/record.url?scp=84881092167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881092167&partnerID=8YFLogxK

U2 - 10.1007/978-1-4419-7219-4_8

DO - 10.1007/978-1-4419-7219-4_8

M3 - Chapter

AN - SCOPUS:84881092167

SN - 9781441972187

SP - 105

EP - 125

BT - Immunologic Signatures of Rejection

PB - Springer New York

ER -