Blood oxygen level dependent angiography (BOLDangio) and its potential applications in cancer research

Kejia Cai, Adam Shore, Anup Singh, Mohammad Haris, Teruyuki Hiraki, Prianka Waghray, Damodar Reddy, Joel H. Greenberg, Ravinder Reddy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Clinically, development of anti-angiogenic drugs for cancer therapy is pivotal. Longitudinal monitoring of tumour angiogenesis can help clinicians determine the effectiveness of anti-angiogenic therapy. Blood oxygen level dependent (BOLD) effect has been widely used for functional imaging and tumour oxygenation assessment. In this study, the BOLD effect is investigated under different levels of oxygen inhalation for the development of a novel angiographic MRI technique, blood oxygen level dependent angiography (BOLDangio). Under short-term (<10 min) generalized hypoxia induced by inhalation of 8% oxygen, we measure BOLD contrast as high as 25% from vessels at 9.4T using a simple gradient echo (GRE) pulse sequence. This produces high-resolution 2D and 3D maps of normal and tumour brain vasculature in less than 10 minutes. Additionally, this technique reliably detects metastatic tumours and tumour-induced intracranial hemorrhage. BOLDangio provides a sensitive research tool for MRI of vasculature under normal and pathological conditions. Thus, it may be applied as a simple monitoring technique for measuring the effectiveness of anti-angiogenic drugs in a preclinical environment.

Original languageEnglish
Pages (from-to)1125-1132
Number of pages8
JournalNMR in Biomedicine
Volume25
Issue number10
DOIs
Publication statusPublished - 1 Oct 2012

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Keywords

  • Blood oxygen level dependent angiography
  • Intracranial hemorrhage
  • MRI
  • Tumour angiogenesis
  • Tumour metastasis
  • Vasculature

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Spectroscopy

Cite this

Cai, K., Shore, A., Singh, A., Haris, M., Hiraki, T., Waghray, P., Reddy, D., Greenberg, J. H., & Reddy, R. (2012). Blood oxygen level dependent angiography (BOLDangio) and its potential applications in cancer research. NMR in Biomedicine, 25(10), 1125-1132. https://doi.org/10.1002/nbm.2780