Biopsy of the posterior interosseous nerve: A low morbidity method for assessment of peripheral nerve disorders

N. O B Thomsen, M. Mojaddidi, Rayaz Malik, L. B. Dahlin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aims: The sural nerve is the commonest peripheral nerve biopsied to help in the diagnosis of peripheral neuropathy of unknown cause. However, associated complications limit its use. The aim was, as an alternative, to asses biopsy of the terminal branch of the posterior interosseous nerve (PIN) in the forearm. Methods: PIN pathology was morphometrically quantified in 10 male patients with Type 2 diabetes and compared with six PIN biopsy specimens taken post mortem from male cadavers with no history of neuropathy or trauma. Results: The PIN biopsy procedure provides a long (approximately 3 cm) mono- or bifascicular nerve biopsy with generous epineurial tissue and adjacent vessels. Our results show a significantly lower myelinated fibre density in subjects with diabetes [5782 (3332-9060)/mm2] compared with autopsy control material [9256 (6593-12 935)/mm2, P < 0.007]. No postoperative discomfort or complications were encountered. Conclusions: A reduction in myelinated fibre density has previously been shown to be a clinically meaningful measure of neuropathy in diabetic patients. We demonstrate similar findings using the PIN biopsy. The PIN biopsy procedure fulfils the criteria for nerve biopsy and was well tolerated by the patients. It may be a possible alternative to sural nerve biopsy to allow for diagnosis of neuropathy.

Original languageEnglish
Pages (from-to)100-104
Number of pages5
JournalDiabetic Medicine
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 2009
Externally publishedYes

Fingerprint

Peripheral Nerves
Morbidity
Biopsy
Sural Nerve
Diabetic Neuropathies
Equidae
Peripheral Nervous System Diseases
Cadaver
Forearm
Type 2 Diabetes Mellitus
Autopsy
Pathology
Wounds and Injuries

Keywords

  • Diabetes
  • Nerve biopsy
  • Neuropathy
  • Posterior interosseous nerve
  • Sural nerve

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Biopsy of the posterior interosseous nerve : A low morbidity method for assessment of peripheral nerve disorders. / Thomsen, N. O B; Mojaddidi, M.; Malik, Rayaz; Dahlin, L. B.

In: Diabetic Medicine, Vol. 26, No. 1, 01.2009, p. 100-104.

Research output: Contribution to journalArticle

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