Beta-blockers are associated with decreased in-hospital mortality and stroke in acute decompensated heart failure: Findings from a retrospective analysis of a 22-year registry in the middle east (1991-2013)

Charbel Abi Khalil, Jassim Al Suwaidi, Rajvir Singh, Nidal Asaad, Galal Abushahba, Unus Kunju, Awad Al-Qahtani, Hajar A. AlBinali

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3 Citations (Scopus)

Abstract

Background: Beta-blockers reduce mortality in chronic heart failure. Objectives: To study intra-hospital mortality and adverse cardiovascular (CV) outcomes in relation to beta-blockade therapy in acute decompensated heart failure. Methods: We retrospectively analyzed a 22-year registry of acute decompensated heart failure (ADHF) in the Middle East. Results: Out of the total 8066 patients admitted for ADHF, 1242(15.4%) were on beta-blockers on admission. Among those, beta-blockers were discontinued in 26.5%. Despite the existence of less CV comorbidities in patients not treated by beta-blockers, in-hospital mortality and stroke/transient ischemic attacks rates were higher in those patients compared with patients on beta-blockers on admission (14.4 vs. 3.6%, p=0.001, 0.6 vs. 0.1%, p=0.02; respectively). Additionally, continuation of beta-blockers during acute decompensation was associated with less mortality risk (p=0.001). The use of beta-blockers on admission and discharge increased significantly with time whereas in-hospital mortality decreased (p=0.001). Nevertheless, admission year was not a predictor of reduced mortality in patients treated with beta-blockers on admission (OR 0.93, 95% CI [0.56-1.54], p=0.77). Conclusion: Previous beta-blockade therapy in patients presenting with ADHF decreases intra-hospital mortality and the incidence of CV events and stroke/transient ischemic attacks. Moreover, nonwithdrawal of beta-blockers during hospitalization has a favorable outcome.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalCurrent Vascular Pharmacology
Volume15
Issue number1
DOIs
Publication statusPublished - 2017
Externally publishedYes

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Keywords

  • Acute decompensated heart failure
  • Beta-blockers
  • Cardiology
  • Cardiovascular disease
  • Heart failure
  • In-hospital mortality

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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