Benextramine and nifedipine distinguish between sub-classes of α1-adrenoceptors

Reza Tabrizhi, Christopher R. Triggle

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of benextramine and nifedipine were examined on the dosediastolic pressure response to methoxamine in pithed normotensive rats. Benextramine (3, 6 and 12 mg/Kg) displaced the dose-response curve to methoxamine to the right. Maximum response was reduced after the administration of 12 mg/Kg benextramine. Nifedipine (0.1 and 0.3 mg/Kg) also caused the dose-response curve to methoxamine to be displaced to the right with reduction in maximum response. Nifedipine effects were additive with an increase in the EC50 values as well as reduction in the maximum response after pretreatment with benextramine (3 and 6 mg/Kg). However, at the highest dose of benextramine the effects of nifedipine were diminished and no longer apparent. It is concluded that benextramine may have alkylated a nifedipine sensitive site on the α1-adrenoceptors.

Original languageEnglish
Pages (from-to)2577-2585
Number of pages9
JournalLife Sciences
Volume45
Issue number26
DOIs
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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