Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes

Vijay Jayagopal, Paula Albertazzi, Eric S. Kilpatrick, Elaine M. Howarth, Paul E. Jennings, David A. Hepburn, Stephen Atkin

Research output: Contribution to journalArticle

246 Citations (Scopus)

Abstract

OBJECTIVE - Phytoestrogen consumption has been shown to reduce risk factors for cardiovascular disease. Type 2 diabetes confers an adverse cardiovascular risk profile particularly in women after menopause. The aim of this study was to determine whether a dietary supplement with soy protein and isoflavones affected insulin resistance, glycemic control, and cardiovascular risk markers in postmenopausal women with type 2 diabetes. RESEARCH DESIGN AND METHODS - A total of 32 postmenopausal women with diet-controlled type 2 diabetes completed a randomized, double blind, cross-over trial of dietary supplementation with phytoestrogens (soy protein 30 g/day, isoflavones 132 mg/day) versus placebo (cellulose 30 g/day) for 12 weeks, separated by a 2-week washout period. RESULTS - Compliance with the dietary supplementation was >90% for both treatment phases. When compared with the mean percentage change from baseline seen after 12 weeks of placebo, phytoestrogen supplementation demonstrated significantly lower mean values for fasting insulin (mean ± SD 8.09 ± 21.9%, P = 0.006), insulin resistance (6.47 ± 27.7%, P = 0.003), HbA1c (0.64 ± 3.19%, P = 0.048), total cholesterol (4.07 ± 8.13%, P = 0.004), LDL cholesterol (7.09 ± 12.7%, P = 0.001), cholesterol/HDL cholesterol ratio (3.89 ± 11.7%, P = 0.015), and free thyroxine (2.50 ± 8.47%, P = 0.004). No significant change occurred in HDL cholesterol, triglycerides, weight, blood pressure, creatinine, dehydroepiandrosterone sulfate, androstenedione, and the hypothalamic-pituitary-ovarian axis hormones. CONCLUSIONS - These results show that dietary supplementation with soy phytoestrogens favorably alters insulin resistance, glycemic control, and serum lipoproteins in postmenopausal women with type 2 diabetes, thereby improving their cardiovascular risk profile.

Original languageEnglish
Pages (from-to)1709-1714
Number of pages6
JournalDiabetes Care
Volume25
Issue number10
DOIs
Publication statusPublished - Oct 2002
Externally publishedYes

Fingerprint

Phytoestrogens
Dietary Supplements
Type 2 Diabetes Mellitus
Insulin Resistance
Soybean Proteins
Isoflavones
HDL Cholesterol
Cholesterol
Placebos
Dehydroepiandrosterone Sulfate
Androstenedione
Menopause
Thyroxine
Cellulose
LDL Cholesterol
Cross-Over Studies
Lipoproteins
Fasting
Creatinine
Triglycerides

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)
  • Advanced and Specialised Nursing

Cite this

Jayagopal, V., Albertazzi, P., Kilpatrick, E. S., Howarth, E. M., Jennings, P. E., Hepburn, D. A., & Atkin, S. (2002). Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care, 25(10), 1709-1714. https://doi.org/10.2337/diacare.25.10.1709

Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. / Jayagopal, Vijay; Albertazzi, Paula; Kilpatrick, Eric S.; Howarth, Elaine M.; Jennings, Paul E.; Hepburn, David A.; Atkin, Stephen.

In: Diabetes Care, Vol. 25, No. 10, 10.2002, p. 1709-1714.

Research output: Contribution to journalArticle

Jayagopal, V, Albertazzi, P, Kilpatrick, ES, Howarth, EM, Jennings, PE, Hepburn, DA & Atkin, S 2002, 'Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes', Diabetes Care, vol. 25, no. 10, pp. 1709-1714. https://doi.org/10.2337/diacare.25.10.1709
Jayagopal V, Albertazzi P, Kilpatrick ES, Howarth EM, Jennings PE, Hepburn DA et al. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care. 2002 Oct;25(10):1709-1714. https://doi.org/10.2337/diacare.25.10.1709
Jayagopal, Vijay ; Albertazzi, Paula ; Kilpatrick, Eric S. ; Howarth, Elaine M. ; Jennings, Paul E. ; Hepburn, David A. ; Atkin, Stephen. / Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. In: Diabetes Care. 2002 ; Vol. 25, No. 10. pp. 1709-1714.
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