Beef Fat Enriched with Polyunsaturated Fatty Acid Biohydrogenation Products Improves Insulin Sensitivity Without Altering Dyslipidemia in Insulin Resistant JCR

LA-cp Rats

Abdoulaye Diane, Faye Borthwick, Cletos Mapiye, Payam Vahmani, Rolland C. David, Donna F. Vine, Michael E.R. Dugan, Spencer D. Proctor

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The main dietary sources of trans fatty acids are partially hydrogenated vegetable oils (PHVO), and products derived from polyunsaturated fatty acid biohydrogenation (PUFA-BHP) in ruminants. Trans fatty acid intake has historically been associated with negative effects on health, generating an anti-trans fat campaign to reduce their consumption. The profiles and effects on health of PHVO and PUFA-BHP can, however, be quite different. Dairy products naturally enriched with vaccenic and rumenic acids have many purported health benefits, but the putative benefits of beef fat naturally enriched with PUFA-BHP have not been investigated. The objective of the present experiment was to determine the effects of beef peri-renal fat (PRF) with differing enrichments of PUFA-BHP on lipid and insulin metabolism in a rodent model of dyslipidemia and insulin resistance (JCR:LA-cp rat). The results showed that 6 weeks of diet supplementation with beef PRF naturally enriched due to flaxseed (FS-PRF) or sunflower-seed (SS-PRF) feeding to cattle significantly improved plasma fasting insulin levels and insulin sensitivity, postprandial insulin levels (only in the FS-PRF) without altering dyslipidemia. Moreover, FS-PRF but not SS-PRF attenuated adipose tissue accumulation. Therefore, enhancing levels of PUFA-BHP in beef PRF with FS feeding may be a useful approach to maximize the health-conferring value of beef-derived fats.

Original languageEnglish
Pages (from-to)821-831
Number of pages11
JournalLipids
Volume51
Issue number7
DOIs
Publication statusPublished - 1 Jul 2016
Externally publishedYes

Fingerprint

Beef
Dyslipidemias
Unsaturated Fatty Acids
Insulin Resistance
Rats
Fats
Insulin
Kidney
Health
Trans Fatty Acids
Plant Oils
Red Meat
Dairy products
Flax
Dairy Products
Helianthus
Ruminants
Insurance Benefits
Nutrition
Lipid Metabolism

Keywords

  • Beef peri-renal fat
  • Flaxseed
  • Insulin sensitivity
  • JCR rats
  • PUFA-BHP
  • Sunflower-seed

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

Cite this

Beef Fat Enriched with Polyunsaturated Fatty Acid Biohydrogenation Products Improves Insulin Sensitivity Without Altering Dyslipidemia in Insulin Resistant JCR : LA-cp Rats. / Diane, Abdoulaye; Borthwick, Faye; Mapiye, Cletos; Vahmani, Payam; David, Rolland C.; Vine, Donna F.; Dugan, Michael E.R.; Proctor, Spencer D.

In: Lipids, Vol. 51, No. 7, 01.07.2016, p. 821-831.

Research output: Contribution to journalArticle

Diane, Abdoulaye ; Borthwick, Faye ; Mapiye, Cletos ; Vahmani, Payam ; David, Rolland C. ; Vine, Donna F. ; Dugan, Michael E.R. ; Proctor, Spencer D. / Beef Fat Enriched with Polyunsaturated Fatty Acid Biohydrogenation Products Improves Insulin Sensitivity Without Altering Dyslipidemia in Insulin Resistant JCR : LA-cp Rats. In: Lipids. 2016 ; Vol. 51, No. 7. pp. 821-831.
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